人参皂苷治疗骨性关节炎的研究进展

Research Progress of Ginsenosides in the Treatment of Osteoarthritis

人参在防治关节软骨损伤退变及参与体外培养软骨细胞修复关节软骨缺损中具有较好治疗前景。人参皂苷作为人参的主要药理活性成分,在治疗骨性关节炎的进程中发挥关键作用。人参皂苷根据不同的结构被分为不同的类型,各类型均含有多种人参皂苷单体成分,其治疗骨性关节炎的机制也各不相同。本文对不同人参皂苷单体治疗骨性关节炎的研究进行梳理和总结,探讨其治疗骨性关节炎的潜在可能性和作用机制,为后期临床应用提供依据。

Ginseng has pharmacological effects such as anti-inflammatory,antioxidant,antidepressant,anti-Alzheimer's and anti-atherosclerosis.Current studies have found that it has good therapeutic prospects in preventing degeneration of articular cartilage damage and participating in in vitro culture of chondrocytes to repair articular cartilage defects.Ginsenosides,as the main pharmacological active component of ginseng,also play an important role in the process of treating osteoarthritis.Ginsenosides can be classified into different types because of their different structures,and each type contains a variety of ginsenoside monomer components with different mechanisms for the treatment of osteoarthritis.In this paper,we reviewthe research progress of different ginsenoside monomers in the treatment of osteoarthritis,and explore their potential possibilities and mechanisms for the treatment of osteoarthritis,so as to provide a basis for later clinical application.