非酒精性脂肪性肝病与冠状动脉粥样硬化及炎症的研究进展

Association of Non-Alcoholic Fatty Liver Disease with Coronary Atherosclerosis and Inflammation

心血管疾病是人类健康的重要问题,随着对非酒精性脂肪性肝病(NAFLD)的深入研究,近年来发现NAFLD与动脉粥样硬化性心血管疾病密切相关,可能会增加冠状动脉钙化及高危斑块的风险。越来越多的证据表明,NAFLD不仅是标志物,还可能参与冠状动脉粥样硬化的发病机制,包括全身炎症、胰岛素抵抗以及血脂异常等。现就近年来对NAFLD与冠状动脉粥样硬化关系认识的进展进行综述,以期提高对早期冠状动脉粥样硬化危险因素的识别。

Cardiovascular disease is an important problem for human health.With the in-depth research on non-alcoholic fatty liver disease(NAFLD),it has been found that NAFLD is closely related to atherosclerotic cardiovascular disease in recent years,which may increase the risk of coronary artery calcification and high-risk plaque.Accumulating evidence suggests that NAFLD is not only a marker,but may also be involved in the pathogenesis of coronary atherosclerosis,including systemic inflammation,insulin resistance and dislipidemia.This article reviews recent advances in the understanding of the relationship between NAFLD and coronary atherosclerosis,with the hope of improving the identification of risk factors for early coronary atherosclerosis.