人体菌群与肺动脉高压的研究进展与展望

Human Microbiota and Pulmonary Hypertension

微生物群在人体健康和疾病的发生发展过程中发挥着重要作用,微生物群稳态及相关代谢产物丰度变化可导致宿主发生一系列生理与病理变化。肺动脉高压(PH)是肺血管系统疾病之一,发病率和死亡率均很高,PH患者如不能得到及时治疗,最终可发展为右心衰竭甚至死亡。近年研究发现,咽部菌群、肺部菌群、肠道菌群与PH的发生发展过程密切相关。现阐述咽部菌群、肺部菌群和肠道菌群与PH之间的关系。

The microbiota plays an important role in the occurrence and development of human health and disease,and changes in the homeostasis and abundance of related metabolite in the microbiota can lead to a series of physiological and pathological changes in the host.Pulmonary hypertension(PH)is one of the pulmonary vascular system diseases with high morbidity and mortality,and patients with PH can eventually develop right heart failure or die if they do not receive timely treatment.In recent years,it has been found that pharyngeal flora,pulmonary flora and intestinal flora are closely related to the occurrence and development of PH.The relationship between pharyngeal flora,pulmonary flora and intestinal flora and PH is now described.