能量失衡经Leptin影响下丘脑Kisspeptin系统的可能机制

Possible Mechanisms of Energy Imbalance Affecting the Hypothalamus Kisspeptin System via Leptin

Kisspeptin系统是连接机体能量平衡与下丘脑-垂体-性腺(hypothalamic–pituitary–gonadal,HPG)轴的重要桥梁。瘦素(Leptin)作为经典的脂肪因子受能量失衡影响后能够直接/间接作用于下丘脑中的Kiss-1神经元,影响Kisspeptin系统的表达,进而调节促性腺激素的分泌和释放,对生殖功能产生影响。从Leptin作用于Kisspeptin系统的分子机制、能量失衡状态下Leptin变化对Kisspeptin系统影响等方面,阐述能量失衡经Leptin对Kisspeptin系统产生影响的可能机制,以期为后续能量失衡与生殖功能相关研究提供帮助。

The Kisspeptin system is an important bridge between energy homeostasis and the hypothalamic-pituitary-gonadal(HPG)axis of the body.Leptin asa classical adipokine,acts on Kiss-1 neurons in the hypothalamus to influence the expression of the Kisspeptin system,which in turn regulates the secretion and release of gonadotropins and impact on reproductive function.This article describes the possible mechanisms of energy imbalance via Leptin on the Kisspeptin system,in terms of the molecular mechanism of direct/indirect action of Leptin on the Kisspeptin system,and the effect of Leptin changes on the Kisspeptin system under the energy imbalance state,in order to provide help for subsequent studies on energy imbalance and reproductive function.