盐酸米诺环素软膏与碘仿纱条填塞拔牙窝治疗干槽症的临床疗效

Clinical Efficacy of Minocycline Hydrochloride Ointment and Iodoform Gauze Filling in Extraction Sockets for Dry Socket Disease

目的:分析盐酸米诺环素软膏与碘仿纱条填塞拔牙窝治疗干槽症的临床效果。方法:选取2019年2月—2022年2月黔西南州牙管家口腔医院收治的干槽症患者68例为研究对象,根据随机数字表法分为纱条组和药物组,各34例。纱条组采用碘仿纱条填塞拔牙窝治疗,药物组采用盐酸米诺环素软膏治疗。比较两组患者治疗效果、疼痛评分、症状缓解时间、牙槽骨组织愈合情况、不良反应发生情况。结果:药物组治疗总有效率高于纱条组,差异有统计学意义(P=0.005);治疗后,两组患者视觉模拟评分法评分均降低,药物组视觉模拟评分法评分低于纱条组,差异有统计学意义(P<0.05);药物组发热及肿胀症状缓解时间均短于纱条组,差异有统计学意义(P=0.000);药物组治疗7、14d后愈合率高于纱条组,愈合时间短于纱条组,差异有统计学意义(P<0.05);药物组不良反应发生率低于纱条组,差异有统计学意义(P=0.019)。结论:对干槽症患者实施盐酸米诺环素软膏治疗效果较佳,安全性较高,可缩短症状缓解时间,降低疼痛程度,牙槽骨组织愈合情况较好。

Objective:To analyze the clinical effect of minocycline hydrochloride ointment and iodoform gauze filling of extraction sockets for the treatment of dry socket.Methods:Sixty-eight patients with dry socket disease admitted to Qianxinan Dental Steward Hospital from February 2019 to February 2022 were selected for the study,and were divided into gauze strip group and drug group according to the random number table method,thirty-four cases each.The gauze strip group was treated with iodoform gauze strips to fill the extraction sockets,and the drug group was treated with minocycline hydrochloride ointment.The treatment effect,pain score,symptom relief time,healing of alveolar bone tissue,and occurrence of adverse reactions were compared between the two groups.Results:The total treatment efficiency of the drug group was higher than that of the gauze strip group,and the difference was statistically significant(P=0.005).After treatment,the visual analog scoring method scores decreased in both groups,and the visual analog scoring method scores in the drug group were lower than those in the gauze strip group,and the difference was statistically significant(P<0.05).The time to relief of fever and swelling in the drug group was shorter than that in the gauze strip group,and the difference was statistically significant(P=0.000).The healing rate in the drug group was higher than that in the gauze strip group after 7 and 14 d of treatment,and the healing time was shorter than that in the gauze strip group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the drug group was lower than that in the gauze strip group,and the difference was statistically significant(P=0.019).Conclusion:The implementation of minocycline hydrochloride ointment in patients with dry socket is more effective and safe,shortens the time to symptom relief,reduces the degree of pain,and heals the alveolar bone tissue better.