摘要
Cell and gene therapy(CGT)shows great therapeutic potential for diverse diseases such as hereditary diseases,cancer,and infectious diseases,with more than 40 food and drug administration(FDA)-approved drugs and lots in preclinical or clinical trials.In the scenario of cell therapy,cells typically isolated from the patients or healthy donors are functionally enhanced in vitro via genome editing before infusion back to patients.
作者
李广磊
章琪
梁廷波
黄行许
Guanglei Li;Qi Zhang;Tingbo Liang;Xingxu Huang(Gene Editing Center,School of Life Science and Technology,ShanghaiTech University,Shanghai 201210,China;Department of Hepatobiliary and Pancreatic Surgery,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;The Key Laboratory of Pancreatic Diseases of Zhejiang Province,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China)
基金
supported by the National Key Research and Development Program of China (2020YFA0804300 and 2021YFA0804702)
the National Natural Science Foundation of China (82188102)。
