色素内镜对犬胃溃疡诊断效果的分析

Analysis of diagnostic effects of chromoendoscopy in canine gastric ulcers

为了解色素内镜对犬胃溃疡的诊断效果,试验选取成年健康的比格犬和泰迪犬各25只,通过内镜引导,使用一次性活检取样钳抓取损伤胃黏膜组织,并配合喷洒pH值为1.0的盐酸溶液模拟胃酸侵蚀,建立犬的胃溃疡病理模型。将建模成功的试验犬在溃疡活动期(A期,造模后第3天)、愈合期(H期,造模后第10天)、瘢痕期(S期,造模后第17天)先后使用普通白光内镜和色素内镜进行检查,分别作为白光内镜组和色素内镜组,对比两组病灶的检出率和清晰度,并根据病灶清晰度评分标准进行评分,判断色素内镜在犬胃溃疡中的诊断效果。结果表明:成功建立胃溃疡模型,溃疡病灶处于A、H、S期时,白光内镜组的检出率分别为72%、56%、48%,色素内镜组的检出率分别为80%、74%、64%,同溃疡活动期色素内镜组的检出率均高于白光内镜组。白光内镜组病灶清晰度评分分别为(3.56±0.54)分、(2.46±0.50)分、(2.14±0.57)分,色素内镜组病灶清晰度评分分别为(4.10±3.67)分、(3.49±0.51)分、(3.02±0.59)分,同溃疡活动期色素内镜组评分均极显著高于白光内镜组(P<0.01)。A、H、S期色素内镜组病灶清晰度评分分别比白光内镜组高0.54分、1.03分、0.88分,约平均提高0.82分。说明使用色素内镜检查犬胃溃疡可以提高病灶的检出率和清晰度,且在溃疡H期时病灶清晰度评分提高最高,优势最为明显。

In order to understand the diagnostic effects of chromoendoscopy in canine gastric ulcers,in this experiment,a total of 25 adult healthy Beagles and 25 Teddy dogs were selected,and the pathological model of gastric ulcer was established by endoscopic guidance,by using disposable biopsy sampling forceps to grasp the damaged gastric mucosal tissue,and spraying hydrochloric acid solution with pH 1 to simulate gastric acid erosion.The successfully modeled test dogs were examined with ordinary white light endoscopy and chromoendoscopy in the ulcer activity phase(stage A,day 3 after molding),healing phase(stage H,day 10 after molding),scarring stage(stage S,day 17 after molding),which were divided into white light endoscopy group and chromoendoscopy group.The detection rate and clarity of the two groups of lesions were compared,and the diagnostic effect of chromoendoscopy in canine gastric ulcer was judged according to the lesion clarity scoring standard.The results showed that the gastric ulcer model was successfully established.When the ulcer lesions were in stage A,H and S,the detection rates of the white light endoscopy group were 72%,56%and 48%respectively;the detection rates of the chromoendoscopy group were 80%,74%and 64%,respectively.And the detection rates of the chromoendoscopy group were higher than those of the white light endoscopy group.The clarity scores of lesions in the white light endoscopy group were(3.56±0.54),(2.46±0.50)and(2.14±0.57)points,respectively;the scores of the chromoendoscopy group were(4.10±3.67),(3.49±0.51)and(3.02±0.59)respectively.The scores of the chromoendoscopy group were significantly higher than those of the white light endoscopy group(P<0.01).The scores of the chromoendoscopy group were 0.54,1.03,0.88 points higher than those of the white light endoscopy group in stage A,H and S,respectively,and the average improvement was about 0.82 points.The results showed that the use of chromoendoscopy to examine canine gastric ulcer could significantly improve the detection rate and clarity of lesions,and the clarity score of lesions was the highest in the H stage of ulcers,and the advantage was the most obvious.