乳腺癌患者肿瘤组织及肠道中失调菌群的系统分析

Systematic analysis of disordered microbiota in tumor tissues and intestine of breast cancer patients

目的 通过文献检索的方式找出在乳腺癌患者的肠道或肿瘤组织中富集且与乳腺癌的发生发展密切相关的菌群。方法采用自由词与主题词检索相结合的方式,根据设定的纳入标准、排除标准,从PubMed、Web of Science、Embase、中国生物医学文献数据库、中国知网、万方数据知识服务平台和维普数据库中检索。检索时间从各数据库建库至2022年3月。依次通过浏览标题、摘要和全文进行文献筛选。结果 共检索出文献1 110篇,纳入30篇,其中16篇文献描述乳腺癌患者乳腺肿瘤组织相对富集菌群,14篇文献描述乳腺癌患者肠道相对富集菌群。与对照组相比较,乳腺癌患者肠道及肿瘤组织中共同富集的菌群有Bacteroides、Lactobacillus和Escherichia coli。结论 乳腺癌患者肠道及肿瘤组织中富集的多种菌群与乳腺癌的发生发展密切相关,肠道及乳腺癌组织中共同富集的Bacteroides、Lactobacillus和Escherichia coli可能与乳腺癌关系最密切,值得深入研究。

Objective To explore the microbiota enriched in the intestinal or tumor tissues of breast cancer(BC)patients and closely related to the occurrence and development of BC through literature search.Methods According to the set inclusion and exclusion criteria,a combination of free word and subject word search was used to search the databases PubMed,Web of Science,Embase,China Biomedical Literature Database,China National Knowledge Infrastructure,Wan-Fang Data Knowledge Service Platform and VIP.The retrieval period was from the establishment of each database to March 2022.Literature selection was carried out by browsing title,abstract and full text successively.Results A total of 1,110 literatures were retrieved and 30 literatures were included.Among them,16 literatures described the relative enrichment of microflora in breast tumor tissues of BC patients,and 14 literatures described the relative enrichment of microbiota in intestine of BC patients.Compared with the control group,the intestinal and tumor tissues of BC patients enriched Bacteroides,Lactobacillus and Escherichia coli.Conclusion A variety of bacteria enriched in the gut and cancer tissues of BC patients are closely related to the occurrence and development of BC.The enrichment of Bacteroides,Lactobacillus and Escherichia coli in tumor tissues and intestine of BC patients is most closely related to BC,which is worth further study.