具核梭杆菌促进结直肠癌发生发展机制的研究进展

Mechanism of Fusobacterium nucleatum promoting the occurrence and development of colorectal cancer:research progress

结直肠癌(colorectal cancer,CRC)是一种全球高发的恶性肿瘤,肠道菌群失调作为潜在致病因素逐渐受到关注。大量的研究发现具核梭杆菌(Fusobacterium nucleatum,F.nucleatum)在CRC组织中丰度显著升高,与CRC的发生有关,目前其具体的作用机制尚不明确。分子及细胞学研究表明F.nucleatum能够破坏肠道上皮屏障、损伤细胞DNA、影响肿瘤相关microRNAs的表达和促进肿瘤细胞转移。本文就F.nucleatum促进CRC发生发展的机制及相关研究进展作一综述。

Colorectal cancer(CRC)is a kind of cancer with high incidence in the world.Intestinal flora dysregulation has been gradually concerned as a potential pathogenic factor.A large number of studies have found that the abundance of Fusobacterium nucleatum in CRC tissues significantly increased,indicating that the bacteria is related to the occurrence of CRC.At present,the specific mechanism is not known yet.Molecular and cytological studies have shown that Fusobacterium nucleatum can destroy intestinal epithelial barrier,damage the DNA of host cells,affect the expression of tumor-related microRNAs and promote tumor cell metastasis.In this paper,the mechanism and progress in related research on Fusobacterium nucleatum promoting the occurrence and development of CRC are reviewed.