miR-31与头颈部肿瘤关系的研究进展

Research progress on the relationship of miR-31 in head and neck tumors

头颈部肿瘤(HNC)是全身最常见的恶性肿瘤之一,主要发生在口腔、咽部和喉部,具有异质性高和病死率高的特点。非编码RNA调控的表观遗传改变在HNC的发生发展中起着重要作用。微小RNA(microRNA,miRNA)是一种小的非编码RNA,通过干扰基因表达来调节细胞周期、增殖、发育、分化和凋亡等。miR-31是一种在恶性肿瘤中研究较为深入的miRNA之一。近年来,愈来愈多的研究探索了miR-31在HNC发生机制、诊断、预后和作为治疗靶点等方面的潜力。本文就miR-31在HNC中的最新研究进展做一综述。

Head and neck tumor(HNC)is one of the most common malignancies worldwide,which mainly occurs in the oral cavity,pharynx and larynx,with high heterogeneity and high mortality.Non-coding RNAs play an important role in the development of HNC by regulating epigenetic alterations.MicroRNAs(miRNAs)are small non-coding RNAs,It regulates cell cycle,proliferation,development,differentiation and apoptosis through gene expression,miR-31 is a well-studied miRNA in malignant tumors.The mechanism of miR31 is as a therapeutic target involved in the occurrence,diagnosis,prognosis and prognosis of HNC in increasing researches.This article reviews the latest research progress of miR-31 in HNC.