血清AMH、性激素及维生素D联合检测在多囊卵巢综合征中的应用价值

Application value of combined detection of serum AMH,sex hormone and vitamin D in polycystic ovary syndrome

目的探讨血清抗米勒管激素(AMH)、性激素及维生素D联合检测对多囊卵巢综合征(PCOS)的诊断价值。方法选择2020年10月至2022年10月该院收治的PCOS患者60例作为观察组,另选择同期该院收治的输卵管性不孕患者60例作为对照组。比较两组患者血清AMH、性激素及维生素D水平,分析血清AMH、性激素及维生素D联合检测对PCOS的诊断价值。结果观察组患者血清促黄体生成素(LH)、睾酮(T)、AMH水平均高于对照组,维生素D水平低于对照组,差异均有统计学意义(P<0.05);两组患者卵泡刺激素、雌二醇、泌乳素、孕酮水平比较,差异均无统计学意义(P>0.05)。受试者工作特征曲线分析显示,血清LH、T、AMH、维生素D单项及联合检测诊断PCOS的曲线下面积(AUC)均>0.80,且以联合检测诊断价值最佳(AUC为0.928)。结论血清LH、T、AMH、维生素D联合检测诊断PCOS的效能高。

Objective To investigate the diagnostic value of combined detection of serum anti-Mullerian hormone(AMH),sex hormone and vitamin D in polycystic ovary syndrome(PCOS).Methods A total of 60 PCOS patients admitted to the hospital from October 2020 to October 2022 were selected as the observation group,and 60 tubal infertility patients admitted to the hospital during the same period were selected as the control group.The levels of serum AMH,sex hormone and vitamin D were compared between the two groups,and the diagnostic value of combined detection of serum AMH,sex hormone and vitamin D for PCOS was analyzed.Results The levels of serum luteinizing hormone(LH),testosterone(T)and AMH in observation group were higher than those in control group,and the level of vitamin D was lower than that in control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the levels of follicle stimulating hormone,estradiol,prolactin,and progesterone between the two groups(P>0.05).Receiver operating characteristic curve analysis showed that the area under the curve(AUC)of serum LH,T,AMH and vitamin D alone and in combination for the diagnosis of PCOS were>0.80,and the combined diagnostic value was the best(AUC=0.928).Conclusion The combined detection of LH,T,AMH and vitamin D has a high diagnostic efficiency for PCOS.