射血分数保留的心力衰竭患者NLR与氨基端前脑钠素及血清炎症因子的相关性分析

Analysis of the correlation among Neutrophil-to-Lymphocyte ratio and NT-proBNP and serum inflammatory factor in heart failure patients with preserved ejection fraction

目的:探讨射血分数保留的心力衰竭(HFpEF)患者中性粒细胞与淋巴细胞比值(NLR)与氨基端前脑钠素(NT-proBNP)以及肿瘤坏死因子(TNF-α)、白介素-6(IL-6)、IL-1β、C反应蛋白(CRP)水平的相关性。方法:随机选取2021年7月-2022年12月北海市人民医院心血管内科收治的三类HFpEF患者共107例,按照葛氏分型分为血管疾病相关HFpEF组(HFpEF-1组)40例,右心和肺相关HFpEF组(HFpEF-3组)29例,瓣膜和节律相关HFpEF组(HFpEF-4组)38例。分析中性粒细胞与淋巴细胞比值和这三类HFpEF患者NT-proBNP以及血清炎症因子TNF-α、IL-6、IL-1β、CRP水平的相关性。结果:①HFpEF-1组和HFpEF-4组患者NLR与NT-proBNP呈直线正相关关系,HFpEF-3组患者NLR与NT-proBNP无直线相关关系。②三组患者NLR与炎症因子TNF-α、IL-6、IL-1β、CRP水平均无直线相关关系。结论:NLR可以作为评估血管疾病相关HFpEF患者及瓣膜和节律相关HFpEF患者心衰严重程度的一个新预测指标,但是NLR无法反映出这三类HFpEF患者的炎症状态。

Objective To discuss the correlation among Neutrophil-to-Lymphocyte ratio and NT-proBNP,serum inflammatory factor TNF-α,IL-6,IL-1β,CRP level in heart failure patients with preserved ejection fraction.Methods From July 2021 to December 2022,a total of 107 three types ejection fraction preserved heart failure patients were selected in the Department of Cardiovascular Medicine,Beihai People’s Hospital,and they were divided into vascular disease related HFpEF group(HFpEF-1 group,n=40),right heart and lung related HFpEF group(HFpEF-3 group,n=29),and valve and rhythm related HFpEF group(HFpEF-4 group,n=38)according to Ge’s typing.Relationship between NLR and NT-proBNP,serum inflammatory factor TNF-α,IL-6,IL-1β,CRP level were discussed in the 3 groups.Results①NLR had positive linear relationship with NT-proBNP in HFpEF-1 and HFpEF-4 patients,while had no linear relationship with NT-proBNP in HFpEF-3 patients.②NLR had no linear relationship with TNF-α,IL-6,IL-1βand CRP level in the 3 groups HFpEF patients.Conclusion NLR can be a novel predictive index to evaluate the severity of heart failure of vascular disease related HFpEF and valve and rhythm related HFpEF patients,while NLR can not reflect the inflammatory state of these three types HFpEF patients.