颈动脉粥样硬化对缺血性脑卒中影响的相关研究进展

Research progress on the effects of carotid atherosclerosis on ischemic stroke

近年来我国动脉粥样硬化性疾病发病率居高不下且呈年轻化趋势,它所导致的急性心脑血管事件的发病率也明显上升。颈动脉粥样硬化(CAS)是导致缺血性脑卒中(IS)发生的重要危险因素之一,占IS病因的7%~18%。CAS的早期发现、早期治疗能显著降低IS的发生率、致残率和死亡率。本文通过对相关研究文献的整理,总结CAS与IS的相关危险因素、CAS致IS发生的相关机制,并在治疗方面总结手术与非手术方式对预防IS发生的有效性,以期能根据IS风险分层为CAS患者选择合理的治疗方式。

In China,the incidence of atherosclerotic diseases has remained high in recent years and shows a younger trend,while the incidence of acute cardiovascular and cerebrovascular events caused by them has also increased significantly.Carotid atherosclerosis(CAS)is one of the important risk factor for ischemic stroke(IS),accounting for 7%to 18%of all causes of IS.Early detection and treatment of CAS can significantly reduce its incidence,disability,and mortality rate.This paper summarizes the risk factors of CAS and IS and the relevant mechanisms of IS caused by CAS and the effectiveness of surgical and non-surgical methods in preventing the occurrence of IS in terms of treatment,in or-der to choose an appropriate treatment approach for CAS patients based on IS risk stratification.