银杏酮酯滴丸联合注射用血栓通治疗急性脑梗死对血脂、神经功能和生活质量的影响

Effect of ginkgo ketone ester dropping pills combined with Xueshuantong on blood lipid,nerve function and quality of life in patients with acute cerebral infarction

目的 分析急性脑梗死(ACI)应用银杏酮酯滴丸联合注射用血栓通治疗的效果及对患者血脂、神经功能、生活质量的影响。方法 120例ACI患者,随机分为对照组和观察组,各60例。对照组患者采用注射用血栓通治疗,观察组采用银杏酮酯滴丸联合注射用血栓通治疗。比较两组患者的临床疗效、血脂指标[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)]及美国国立卫生研究院卒中量表(NIHSS)、神经功能缺损量表(NFDS)、Barthel指数(BI)评分。结果 治疗前,两组TG、TC、LDL-C水平比较差异无统计学意义(P>0.05);治疗后,两组TG、TC、LDL-C水平均低于治疗前,且观察组TG(1.30±0.33)mmol/L、TC(4.04±0.76)mmol/L、LDL-C(2.47±0.28)mmol/L明显低于对照组的(1.52±0.45)、(4.72±0.93)、(2.78±0.30)mmol/L,差异有统计学意义(P<0.05)。治疗前,两组NIHSS、NFDS和BI评分比较差异无统计学意义(P>0.05);治疗后,两组NIHSS、NFDS评分均低于治疗前,BI评分均高于治疗前,且观察组NIHSS评分(5.13±1.49)分、NFDS评分(11.20±4.40)分均低于对照组的(7.41±1.94)、(17.40±4.80)分,BI评分(62.77±10.73)分高于对照组的(53.55±9.69)分,差异有统计学意义(P<0.05)。观察组总有效率81.7%高于对照组的60.0%,差异有统计学意义(P<0.05)。结论 采用银杏酮酯滴丸联合注射用血栓通治疗ACI可提高患者的整体疗效,明显改善血脂水平、神经功能损伤和生活质量,临床可积极应用。

Objective To analyze the effect of ginkgo ketone ester dropping pills combined with Xueshuantong on blood lipid,nerve function and quality of life in patients with acute cerebral infarction(ACI).Methods A total of 120 ACI patients were randomly divided into control group and observation group,with 60 cases in each group.The control group was treated with Xueshuantong for injection,and the observation group was treated with ginkgo ketone ester dropping pills and Xueshuantong for injection.Both groups were compared in terms of clinical efficacy,blood lipid indexes[triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)],National Institutes of Health Stroke Scale(NIHSS)score,Neurological Function Defect Scale(NFDS)and Barthel index(BI)score.Results Before treatment,there were no statistically significant differences in TG,TC and LDL-C levels between the two groups(P>0.05).After treatment,TG,TC and LDL-C levels in both groups were lower than those before treatment in this group;the observation group had TG of(1.30±0.33)mmol/L,TC of(4.04±0.76)mmol/L and LDL-C of(2.47±0.28)mmol/L,which were significantly lower than those of(1.52±0.45),(4.72±0.93)and(2.78±0.30)mmol/L in the control group;the differences were statistically significant(P<0.05).Before treatment,there were no statistically significant differences in NIHSS,NFDS and BI scores between the two groups(P>0.05).After treatment,NIHSS and NFDS scores in the two groups were lower than those before treatment in this group,while BI score were higher than that before treatment in this group;NIHSS score of(5.13±1.49)points and NFDS score of(11.20±4.40)points in the observation group were lower than those of(7.41±1.94)and(17.40±4.80)points in the control group;BI score of(62.77±10.73)points in the observation group was higher than that of(53.55±9.69)points in the control group;the differences were statistically significant(P<0.05).The total effective rate of the observation group was 81.7%,which was higher than that of 60.0%of the control group,and the difference was statistically significant(P<0.05).Conclusion Ginkgo ketone ester dropping pills combined with Xueshuantong for injection can improve the overall efficacy of ACI patients,and significantly improve the level of blood lipids,neurological function defect and quality of life,which can be actively used in clinic.