1990-2019年中国卵巢癌疾病负担及其变化趋势分析

Disease Burden and Its Trends of Ovarian Cancer in China from 1990 to 2019

[目的]分析1990-2019年中国卵巢癌疾病负担长期变化趋势.[方法]通过全球疾病负担研究(GBD)数据,应用Joinpoint 4.9.1.0软件分析1990-2019年中国卵巢癌标化患病率、发病率、死亡率、伤残调整寿命年(DALYs)、过早死亡损失寿命年(YLLs)和伤残损失寿命年(YLDs)等指标的平均年度变化百分比(AAPC).[结果]1990-2019年中国卵巢癌的患病数、发病数和死亡数均有明显增加.标化患病率从10.11/10万增加至20.44/10万,标化发病率从2.56/10万增加至4.54/10万,标化死亡率从1.76/10万增加至2.77/10万,标化DALYs率从55.57/10万增加至80.52/10万.标化患病率、标化发病率、标化死亡率、标化DALYs率、标化YLLs率和标化YLDs率整体均呈上升趋势,AAPC值分别为2.48%、2.02%、1.58%、1.32%、1.32%和2.26%,差异均具有统计学意义(P<0.001).从35岁开始卵巢癌疾病负担快速上升,发病率和DALYs率在65~69岁组最高,死亡率在≥70岁组最高.[结论]1990-2019年中国卵巢癌疾病负担有明显上升趋势,且老年人增加更为明显,应尽快完善三级预防策略,加强女性生殖系统的健康宣教,以有效减少卵巢癌的发病和死亡.

[Purpose]To investigate the trends of disease burden of ovarian cancer in China from 1990 to 2019.[Methods]Based on the Global Burden of Disease(GBD)Study,the Joinpoint 4.9.1.0 software was used to analyze the average annual percentage change(AAPC)of standardized prevalence rate,standardized incidence rate,standardized mortality rate,standardized disability-adjusted life years(DALYs)rate,standardized years of life lost(YLLs)and standardized years lived with disability(YLDs)rate of ovarian cancer in China from 1990 to 2019.[Results]From 1990 to 2019,the standardized prevalence rate increased from 10.11/105 to 20.44/105,the standardized incidence rate from 2.56/105 to 4.54/105,the mortality rate from 1.76/105 to 2.77/105,and the DALYs rate from 55.57/105 to 80.52/105 in China.The standardized prevalence rate(AAPC=2.48%),standardized incidence rate(AAPC=2.02%),standardized mortality rate(AAPC=1.58%),standardized DALYs rate(AAPC=1.32%),standardized YLLs rate(AAPC=1.32%)and standardized YLDs rate(AAPC=2.26%)showed an upward trend(P<0.001).The disease burden of ovarian cancer increased rapidly after the age of 35.The incidence and DALYs rates at the age group of 65~69 years were the highest,and the mortality rate at the age group of 70 years and older was the highest among all age groups.[Conclusion]From 1990 to 2019,the disease burden of ovarian cancer in China shows an upward trend,particularly in the elderly population.The three-tier prevention strategy should be strengthened to reduce the incidence and mortality of ovarian cancer.