仔猪产肠毒素大肠杆菌疫苗的研究进展

Research Progress of Enterotoxigenic Escherichia coli Vaccine for Piglets

仔猪腹泻仍然是困扰世界养猪业的重要疾病之一,产肠毒素大肠杆菌(ETEC)是引起仔猪腹泻的重要病原菌。在饲料中添加抗生素、喂服特异性抗体、膳食调节、利用遗传育种选育等多种方法被用来预防和治疗ETEC引起的感染。相比其他预防措施,疫苗接种是防制ETEC引起仔猪腹泻的最经济和最有效的手段。就目前猪用ETEC疫苗的最新研究进展进行综述,并分析了ETEC疫苗研究中面临的挑战,提出了高效疫苗的研究策略,旨在为ETEC新型、安全、高效和广谱疫苗的研发提供依据。

Enterotoxigenic Escherichia coli(ETEC)is an important pathogen causing diarrhea of piglets in the world.Various strategies such as giving antibiotics in the feed,oral administration of specific antibodies,dietary and diet supplementary treatment,and genetic breeding have been used to prevent and treat ETEC infection.Compared with other preventive measures,vaccination is the most economical and effective mean to prevent diarrhea of piglets caused by ETEC.In this paper,the latest research progress of ETEC vaccine for porcine was reviewed,the challenges in ETEC vaccine research were analyzed,and the research strategies for effective vaccines were proposed,in order to provide the basis for the development of novel,safe,efficient and broad-spectrum ETEC vaccines.