血清CEA、Ang-2预测大肠癌术后复发的价值

The Value of Serum CEA and Ang-2 in Prognosticating Postoperative Recurrence of Large Intestinal Cancer

目的:探讨血清癌胚抗原(CEA)、促血管生成素-2(Ang-2)预测大肠癌术后复发的价值。方法:选取我院2019-2021年收治的60例大肠癌患者为研究参与者,患者均接受手术和化疗治疗,展开为期1年随访,根据患者术后复发情况分为复发组12例和未复发组48例。比较2组患者术前血清CEA、Ang-2水平以及临床资料,通过Logistic分析大肠癌患者术后复发的危险因素,绘制ROC曲线分析血清CEA、Ang-2对大肠癌复发的预测价值。结果:2组患者在分化程度、肿瘤分期、淋巴结转移情况、术前血清CEA、Ang-2水平方面比较差异具有统计学意义(P<0.05);分化程度、肿瘤分期、淋巴结转移情况、术前血清CEA、Ang-2水平均是大肠癌患者术后复发的危险因素(P<0.05);术前CEA和Ang-2两者联合预测术后复发的灵敏度和特异度分别为83.3%和85.4%,均高于各项指标单独检测(P<0.05)。结论:血清CEA、Ang-2预测大肠癌术后复发的价值较高,且是大肠癌复发的独立危险因素。

Objective To explore the value of serum CEA and Ang-2in prognosticating postoperative recurrence of large intestinal cancer.Methods Enrolled 60patients with large intestinal cancer treated in author's hospital(2019-2021)as research participant:they all received surgery and chemotherapy,also were followed-up for 1year,then,according to their recurrence status divided them into recurrence group(12cases)and non-recurrence group(48cases);then,compared both groups'preoperative levels of serum CEA and Ang-2,as well as clinical data,by using Logistic analysis analysed recurrence risk factors,drew ROC further analysed the value of serum CEA and Ang-2in prognosing the recurrence.Results Between both groups in differentiation degree,tumor stage,lymphnode metastasized,as well as preoperative levels of serum CEA and Ang-2there was statistical difference(P<0.05),which above-mentioned four factors were all the risk factors influencing the recurrence(P<0.05);the preoperatively combined detecting of serum CEA and Ang-2in the sensitivity and specificity for prognosing recurrence were respectively 83.5%and 85.4%,which were all higher the single detection of serum CEA,or Ang-2(P<0.05).Conclusion The serum CEA and Ang-2prognosing recurrence after surgery for large intestinal cancer has higher value,at the same time,the two factors also are the independent risk factors influencing the recurrence.