炎性乳腺癌中肿瘤微环境的研究进展

Advances on Tumor Microenvironment in Inflammatory Breast Cancer

炎性乳腺癌(IBC)是一种罕见且进展迅速的高侵袭性乳腺癌亚型。因其在起病初期常被误诊,对标准治疗反应较差以及缺少大样本的前瞻性研究,IBC患者的生存率明显低于非炎性乳腺癌患者。国内外一直致力于阐释IBC的各方面生物学机制,而作为肿瘤免疫最直接的表现形式,肿瘤微环境(TME)参与了IBC的各种恶性生物学行为。IBC的TME中包括淋巴管、血管、肿瘤相关成纤维细胞、肿瘤细胞外基质及浸润性免疫细胞等组成成分,但无明确特征,各种调控TME中免疫细胞的分子机制和信号通路在很大程度上仍不清楚。全文就IBC的TME与IBC发病机制及其预后的相关性进行综述。

Inflammatory breast cancer(IBC) is a rare and highly aggressive subtype of breast cancer. The survival rate of patients with IBC is significantly lower than that of patients with non-inflammatory breast cancer. IBC is likely to be misdiagnosis in the early stages and poorly responses to standard therapies, and there is lack of large prospective studies for this type of breast cancer. In recent years, many studies intended to elucidate the biological mechanisms of IBC, including the roles of tumor microenvironment(TME). As important aspect of tumor immunity, TME is deeply involved in various malignant biological behaviors of IBC. The TME of IBC includes lymphatic vessels, blood vessels, tumor-associated fibroblasts, tumor extracellular matrix and infiltrating immune cell. However, the molecular mechanisms and signaling pathways regulating immune cells in TME remain largely unclear. This paper reviews the relationship between the tumor microenvironment and the pathogenesis and prognosis of inflammatory breast cancer.