银杏二萜内酯葡胺注射液联合阿替普酶治疗急性脑梗死的临床效果观察

Clinical observation of ginkgo diterpene lactone meglumine injection combined with alteplase in the treatment of acute cerebral infarction

目的 观察急性脑梗死治疗中阿替普酶联合银杏二萜内酯葡胺注射液治疗的临床效果。方法 80例急性脑梗死患者,依据治疗方法不同分为联合治疗组与单独治疗组,各40例。联合治疗组采用阿替普酶联合银杏二萜内酯葡胺注射液治疗,单独治疗组采用阿替普酶单独治疗。比较两组治疗前后的相关评分[美国国立卫生研究院卒中量表(NIHSS)、简易智能状态检查表(MMSE)、日常生活能力量表(ADL)、改良Rankin量表(mRS)评分]、临床疗效、不良反应发生情况。结果 治疗后,两组NIHSS评分、MMSE评分、ADL评分、mRS评分均较治疗前改善,且联合治疗组患者的NIHSS评分(10.28±1.14)分、ADL评分(26.30±2.30)分、mRS评分(1.83±0.32)分低于单独治疗组的(13.50±1.45)、(32.04±2.75)、(2.78±0.44)分,MMSE评分(28.46±3.15)分高于单独治疗组的(24.76±2.48)分,差异有统计学意义(P<0.05)。联合治疗组治疗总有效率97.50%(39/40)高于单独治疗组的65.00%(26/40),差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论 急性脑梗死治疗中应用阿替普酶联合银杏二萜内酯葡胺注射液治疗的临床效果显著,较阿替普酶单独治疗好,值得临床推广应用。

Objective To observe the clinical effect of ginkgo diterpene lactone meglumine injection combined with alteplase in the treatment of acute cerebral infarction.Methods A total of 80 patients with acute cerebral infarction were divided into combined treatment group and single treatment group according to different treatment methods,with 40 cases in each group.The combined treatment group was treated with alteplase and ginkgo diterpene lactone meglumine injection,and the single treatment group was treated with alteplase alone.Both groups were compared in terms of relevant scores[National Institutes of Health Stroke Scale(NIHSS),Mini-Mental State Examination(MMSE),Activities of Daily Living Scale(ADL),modified Rankin Scale(mRS)scores]before and after treatment,clinical efficacy,and occurrence of adverse reactions.Results After treatment,NIHSS score,MMSE score,ADL score and mRS score in both groups were improved compared with those before treatment in this group;the combined treatment group had NIHSS score of(10.28±1.14)points,ADL score of(26.30±2.30)points and mRS score of(1.83±0.32)points,which were lower than those of(13.50±1.45),(32.04±2.75)and(2.78±0.44)points in the single treatment group;MMSE score of(28.46±3.15)points in the combined treatment group was higher than that of(24.76±2.48)points in the single treatment group;the differences were statistically significant(P<0.05).The total effective rate of 97.50%(39/40)in the combined treatment group was higher than that of 65.00%(26/40)in the single treatment group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical effect of alteplase combined with ginkgo diterpene lactone meglumine injection in the treatment of acute cerebral infarction is significant and better than alteplase alone,which is worthy of clinical promotion and application.