地诺前列酮与米索前列醇应用于促宫颈成熟的临床效果对比研究

Comparative Study on the Clinical Effects of Dinoprostone and Misoprostol in Promoting Cervical Maturity

目的:对比研究地诺前列酮与米索前列醇应用于促宫颈成熟的临床效果。方法:选取航空总医院2019年2月—2022年7月收治的足月妊娠且宫颈未成熟患者160例。应用随机数表法将其分成两组,各80例。地诺前列酮组应用地诺前列酮促宫颈成熟,米索前列醇组应用米索前列醇促宫颈成熟,对比两组促宫颈成熟的效果、分娩方式、分娩结局及并发症发生情况。结果:治疗前,两组宫颈成熟评分比较,差异无统计学意义(P>0.05)。治疗后,两组宫颈成熟评分均高于治疗前,且地诺前列酮组高于米索前列醇组,差异有统计学意义(P<0.05)。地诺前列酮组自然分娩率为87.50%,高于米索前列醇组的71.25%,差异有统计学意义(P<0.05)。地诺前列酮组剖宫产率低于米索前列醇组,差异有统计学意义(P<0.05)。两组产后2 h出血量比较,差异无统计学意义(P>0.05)。地诺前列酮组总产程时间、用药至临产时间均短于米索前列醇组,新生儿5 min Apgar评分高于米索前列醇组,差异有统计学意义(P<0.05)。地诺前列酮组并发症总发生率为26.25%,高于米索前列醇组的23.75%,但组间比较差异无统计学意义(P>0.05)。结论:地诺前列酮与米索前列醇均可应用于促宫颈成熟,但相对来说地诺前列酮的临床效果更好,可促进自然分娩,减少剖宫产率,提高新生儿Apgar评分,减少产程时间,更加适合临床选择应用。

Objective:To compare and study the clinical effect of Dinoprostone and Misoprostol in promoting cervical maturation.Method:A total of 160 patients with full-term pregnancy and immature cervix admitted to Aviation General Hospital from February 2019 to July 2022 were selected.They were divide into two groups using the random number table method,with 80 cases in each group.Dinoprostone group was applied with Dinoprostone to promote cervical maturity,and Misoprostol group was applied with Misoprostol to promote cervical maturity.The effect of cervical maturity,delivery method,delivery outcome and the occurrence of complications of the two groups were compared.Result:Before treatment,there was no significant difference in cervical maturity score between the two groups(P>0.05).After treatment,cervical maturity scores in both groups were higher than those before treatment,and Dinoprostone group was higher than that in the Misoprostol group,the differences were statistically significant(P<0.05).The rate of natural delivery in Dinoprostone group was 87.50%,which was higher than 71.25%in Misoprostol group,and the difference was statistically significant(P<0.05).The cesarean section rate in Dinoprostone group was lower than that in Misoprostol group,and the difference was statistically significant(P<0.05).There was no significant difference in postpartum blood loss at 2 h between the two groups(P>0.05).The total process of labor and the time from medication to labor in the Dinoprostone group were shorter than those in the Misoprostol group,and the 5 min Apgar score of newborns was higher than that in the Misoprostol group,the differences were statistically significant(P<0.05).The total complication rate of Dinoprostone group was 26.25%,which was higher than 23.75%of Misoprostol group,and the difference was not statistically significant(P>0.05).Conclusion:Both Dinoprostone and Misoprostol can be used to promote cervical maturation,but relatively speaking,Dinoprostone has better clinical effects,promoting natural delivery,reducing cesarean section rate,improving newborns Apgar score,reducing labor process time,and making it more suitable for clinical selection and application.