不同剂量丙种球蛋白联合阿司匹林治疗川崎病患儿的效果

Effect of Different Doses of Gamma Globulin Combined with Aspirin in the Treatment of Children with Kawasaki Disease

目的:分析不同剂量丙种球蛋白联合阿司匹林治疗川崎病患儿的效果。方法:回顾性选取2020年3月—2022年4月于福建省福州儿童医院治疗的120例川崎病患儿的资料。根据治疗方法将其分为常规组与研究组,各60例。常规组给予常规剂量丙种球蛋白联合阿司匹林肠溶片进行治疗,研究组给予大剂量丙种球蛋白联合阿司匹林肠溶片治疗。比较两组治疗前后炎症因子、免疫功能、N末端脑利纳肽原(NT-proBNP)水平、红细胞沉降率(ESR)、降钙素原(PCT),症状消退时间、不良反应及临床疗效。结果:治疗后,研究组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)、NT-proBNP、ESR、PCT水平均低于常规组,研究组CD3^(+)、CD4^(+)、CD8^(+)均高于常规组,差异有统计学意义(P<0.05)。研究组下肢肿胀消退时间、发热消退时间、躯干红斑消退时间、淋巴结肿大消退时间、结膜充血消退时间均早于常规组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。研究组总有效率高于常规组,差异有统计学意义(P<0.05)。结论:大剂量丙种球蛋白联合阿司匹林治疗川崎病患儿可有效降低NT-pro BNP、ESR水平,使炎症因子、免疫功能指标趋于正常,改善临床症状,效果显著。

Objective:To analyze the effect of different doses of Gamma Globulin combined with Aspirin in the treatment of children with Kawasaki disease.Method:The data of 120 children with Kawasaki disease treated in Fuzhou Children's Hospital of Fujian Province from March 2020 to April 2022 were retrospectively selected.According to the treatment method,they were divided into routine group and study group,60 cases in each group.The routine group was treated with conventional dose of Gamma Globulin combined with Aspirin Enteric-coated Tablets,and the study group was treated with high dose of Gamma Globulin combined with Aspirin Enteric-coated Tablets.The inflammatory factors,immune function,N-terminal pro-brain linatide(NT-proBNP)level and erythrocyte sedimentation rate(ESR),procalcitonin(PCT)before and after treatment,symptom resolution time,adverse reactions and clinical efficacy were compared between the two groups.Result:After treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),C-reactive protein(CRP),NT-proBNP,ESR,PCT in the study group were lower than those in the routine group,and the levels of CD3^(+),CD4^(+) and CD8^(+) in the study group were higher than those in the routine group, and the differences were statistically significant (P<0.05). The regression time of lower limb swelling, fever, trunk erythema, lymph node enlargement and conjunctival hyperemia in the study group were earlier than those in the routine group, and the differences were statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). The total effective rate of the study group was higher than that of the routine group, and the difference was statistically significant (P<0.05). Conclusion: High dose of Gamma Globulin combined with Aspirin in the treatment of children with Kawasaki disease can effectively reduce the levels of NT-proBNP and ESR, make the inflammatory factors and immune function indicators tend to normal, improve the clinical symptoms, and the effect is significant.