不同分子亚型乳腺癌患者DCE-MRI定量参数的应用价值

Quantitative Parameters of DCE-MRI in Breast Cancer Patients with Different Molecular Subtypes and Their Relationship with Angiogenesis

目的:研究分析不同分子亚型乳腺癌患者DCE-MRI定量参数及其与血管生产指标的关系。方法:选取2020年3月至2022年12月期间在我院接受治疗的乳腺癌患者共计102例,通过对患者进行乳腺DCE-MRI扫描,手术后对切除病变实施临床病理与免疫组织化学检验,结合免疫组织化学结果,进行不同分子亚型划分,分析不同分子亚型患者DCE-MRI定量参数变化情况。结果:在102例乳腺癌患者中,通过免疫组化检验显示,Luminal A型共有14例,Luminal B型共有57例,HER-2过表达型共有21例,三阴型共有10例;根据速率常数对比结果显示,Luminal A型<Luminal B型<三阴型<HER-2过表达型,有明显统计学意义(P<0.05);相较于PR阴性,阳性容量转移常数、速率常数水平较低,计算结果有统计学差异,P<0.05。结论:不同分子亚型乳腺癌患者DCE-MRI定量参数组间对比差异明显,能够提高不同分子亚型乳腺癌的诊断有效性。

Objective:To study and analyze the relationship between quantitative parameters of DCE-MRI and vascular production in patients with different molecular subtypes of breast cancer.Methods:A total of 102 patients with breast cancer who were treated in our hospital from March 2020 to December 2022 were selected.The patients were scanned by DCE-MRI,and the resected lesions were examined by clinicopathology and immunohistochemistry after surgery.Combined with the immunohistochemical results,different molecular subtypes were classified,and the changes of quantitative parameters of DCE-MRI in patients with different molecular subtypes were analyzed.Results:(1)Among 102 cases of breast cancer patients,immunohistochemistry results showed that there were 14 cases of Luminal A type,57cases of Luminal B type,21 cases of HER-2 overexpression type,and 10 cases of triple negative type;(2)According to the results of rate constant comparison,Luminal A typeLuminal B typetriple negative typeHER-2 overexpression type,which was statistically significant(P<0.05);(3)Compared to PR negative,the level of positive volume transfer constant and rate constant is lower,and the statistical results are P<0.05.Conclusion:The quantitative parameters of DCE-MRI in patients with different molecular subtypes of breast cancer are significantly different between groups,which can improve the diagnostic effectiveness of different molecular subtypes of breast cancer.