甲基硫醚基团的官能化研究

FUNCTIONALIZATION OF METHYLTHIO DERIVATIVES

本研究以甲基硫醚与溴代烷为原料,以生成热力学更稳定的硫醚为驱动力,在相对温和的条件下通过一锅法直接制备新的硫醚衍生物。该方法避免了使用过渡金属,额外的添加剂以及严格的无水无氧条件,而且底物范围广,平均收率大于70%。通过本研究发展的硫醚官能化方法,成功对一系列的芳香/脂肪烷基甲基硫醚衍生物实现了进一步烷基化,包括非天然甲硫氨酸单体合成子的制备。

An efficient method for one-pot preparing thioether had been developed by employing methylthio derivative and bromoalkane,which was driven by the formation of a more thermodynamic stable thioether.This approach was transition-metal-free and could be conducted under air.Moreover,this reaction was with broad substrate scope and high yield(>70%).A series of aromatic/aliphatic alkyl methyl thioether derivatives could be alkylated successfully,including the preparation of an unnatural methionine synthon.