女方年龄对夫精人工授精妊娠结局的影响

Influence of female age on pregnancy outcome after artificial insemination by husband

目的 探讨女方年龄对夫精人工授精(AIH)妊娠结局的影响。方法 回顾性分析596例不孕症患者(共计1108个周期)的病历资料,依据年龄划分成≥35岁组(n=356个周期)与<35岁组(n=752个周期);并将≥35岁组划分为<40岁组(n=289个周期)与≥40岁组(n=65个周期)。比较不同年龄患者的一般资料及AIH妊娠结局。结果 年龄<35岁组的AIH临床妊娠率(14.89%)与年龄≥35岁组(11.23%)比较,差异无统计学意义(P>0.05);年龄<35岁组的自然流产率(11.61%)低于年龄≥35岁组(27.50%),差异有统计学意义(P<0.05);35岁≤年龄<40岁组与年龄≥40岁组的临床妊娠率(11.76%vs.9.23%)以及自然流产率比较(26.47%vs.33.33%),差异无统计学意义(P>0.05)。结论 对于高龄不孕症患者,AIH助孕自然流产率较高,临床妊娠率较低。

Objective To investigate the influence of the female age on the pregnancy outcome of artificial insemination by husband(AIH).Methods The medical records of 596 infertile patients(1108 cycles in total) who underwent AIH were analyzed retrospectively.They were divided into the ≥35 years old group(n=356 cycles) and the35 years old group(n=752 cycles)according to age.The ≥35 years old group was divided into the40 years old group(n=289 cycles) and the ≥ 40 years old group(n=65 cycles).The general information of patients of different ages and pregnancy outcome of AIH were compared.Results There was no significant difference in the clinical pregnancy rate of AIH between the35 years old group(14.89%) and the ≥35 years old group(11.23%)(P>0.05).The spontaneous abortion rate in the35 years old group(11.61%) was lower than that in the ≥35 years old group(27.50%),with significant difference(P<0.05).There were no significant differences in the clinical pregnancy rate(11.76%vs.9.23%) and the spontaneous abortion rate(26.47% vs.33.33%) between the 35 years ≤ age<40 years group and the ≥ 40 years old group(P>0.05).Conclusion For the elderly patients with infertility,AIH assisted pregnancy has a higher rate of spontaneous abortion and a lower clinical pregnancy rate.