纺锤体检测点蛋白在恶性肿瘤中的研究进展

Research progress of spindle monitoring point protein in malignant tumors

恶性肿瘤的发生常伴随细胞周期调控异常、染色体有丝分裂不精准等诸多内在因素的作用。纺锤体装配检验点(SAC)是负责细胞有丝分裂调控的核心元器件之一,SAC的异常会导致染色体不稳定增加,从而使细胞更容易发生恶性改变,随着对肿瘤细胞有丝分裂研究的深入这一观点已经被逐步证实。纺锤体检测点蛋白(BUB1B)作为SAC的重要组成部分之一,其经典作用是通过信号传导组织细胞从有丝分裂中期进入后期直到所有染色体黏附至纺锤体之上。目前,BUB1B已经被证实在乳腺癌、结直肠癌、卵巢癌、膀胱癌、胰腺癌等多种恶性肿瘤中过表达,并且具有作为新的临床生物学诊断标志物和肿瘤靶向治疗的潜力。文章对BUB1B在恶性肿瘤中的研究进展进行综述。

The occurrence of malignant tumors is often accompanied by many internal factors,such as abnormal cell cycle regulation,inaccurate chromosome mitosis and so on.Spindle assembly checkpoint(SAC)is one of the core components responsible for the regulation of cell mitosis.The abnormality of sac will lead to the increase of chromosome instability,which makes cells more prone to malignant changes.With the in⁃depth study of tumor cell mitosis,this view has been gradually con⁃firmed.As one of the important components of sac,spindle monitoring site protein(BUB1B)plays a classic role in organizing cells from metaphase to anaphase through signal transduction until all chromosomes adhere to the spindle.At present,BUB1B has been confirmed to be overexpressed in breast cancer,colorectal cancer,ovarian cancer,bladder cancer,pancreatic cancer and other malignant tumors,and has the potential to be used as a new clinical biological diagnostic marker and tumor targeted therapy.This article reviews the research progress of BUB1B in malignant tumors.