睾丸巨噬细胞的研究进展

Research progress of testicular macrophages

睾丸作为重要的男性生殖器官,具有复杂的生殖-内分泌-免疫调控网路。睾丸巨噬细胞在血管形成、精子发生、类固醇激素生成、免疫抑制和细菌病毒感染等方面有着非常重要的作用。本文通过综述睾丸巨噬细胞的定位、分类、发育来源以及功能等来说明其在睾丸中的地位及意义,以期为研究睾丸巨噬细胞的功能和治疗男性不育症、睾丸炎症等提供理论依据。

As an important male reproductive organ,testis has a complex reproductive endocrine immune regulatory network.Testicular macrophages play an important role in angiogenesis,spermatogenesis,testosterone production,immunosuppression,and bacterial/viral infection.In this review,we discuss the location,classification,developmental sources,and functions of testicular macrophages to explain their status and significance in testis,providing a theoretical basis for the study of the function of testicular macrophages and the treatment of male infertility and orchitis.