外周巨噬细胞对认知功能的影响

Effect of peripherally derived macrophages on cognition

外周巨噬细胞在中枢神经系统中的作用尚不十分清楚。一般认为,由于血脑屏障的存在,外周巨噬细胞进入脑实质的能力有限。然而,在中枢神经系统损伤或感染以及慢性神经炎症条件下,来源于外周的巨噬细胞也可浸润进入脑实质发挥多种调控作用。巨噬细胞对认知功能的影响通常认为是炎症环境重塑巨噬细胞活性的结果。该文拟对外周巨噬细胞影响神经认知功能的环境及潜在机制作一综述。

The role of peripherally-derived macrophages in the central nervous system(CNS)is unclear.It is generally believed that due to the presence of the blood brain barrier(BBB),the ability of peripheral macrophages to enter the brain parenchyma is limited.However,in case of CNS injury or infection and chronic neuroinflammation,macrophages derived from the periphery can also infiltrate into the brain parenchyma to play a variety of regulatory roles.The effect of macrophages on cognition is generally considered to be due to the reshaping of the activity of macrophages by the inflammatory environment.This review summarizes the environments and potential mechanisms by which macrophages affect cognition.