抑制心血管疾病铁死亡药物的研究进展

Research progress in drugs that inhibit ferroptosis in cardiovascular diseases

铁死亡是一种铁离子依赖的、以脂质活性氧簇累积为主要标志的全新程序性细胞死亡方式。铁死亡参与许多病理过程,除与肿瘤、老年性疾病、神经退行性疾病、代谢性疾病等发生发展密切相关外,还参与了心力衰竭、心肌病、冠状动脉粥样硬化等多种疾病过程。该文对铁死亡在心血管疾病中各种病理机制进行了综述,并简要阐述各类药物对铁死亡的作用,以提高人们对铁死亡作为心血管疾病治疗新靶点的认识。

Ferroptosis is a new form of programmed cell death,which is iron-dependent and marked by the accumulation of lipid reactive oxygen clusters.Ferroptosis is involved in many pathological processes,which is not only closely related to the development of tumors,senile diseases,neurodegenerative diseases and metabolic diseases,but also involved in heart failure,cardiomyopathy,coronary atherosclerosis and other diseases.This article reviews the various pathological mechanisms of ferroptosis in cardiovascular diseases,and describes the effects of various drugs on ferroptosis in order to advance our understanding of ferroptosis as a new target in the treatment of cardiovascular diseases.