母体糖尿病对子代肾脏发育影响的研究进展

Progress in the effect of maternal diabetes on the kidney development in offspring

母体糖尿病不仅和孕母自身健康密切相关,也会对子代健康产生重要影响。不良的孕前及宫内环境会影响子代肾脏正常发育过程,进而增加其成年期肾脏疾病的患病风险。该文阐述了母体糖尿病对子代肾脏结构和功能的影响。母体糖尿病会增加子代先天性肾脏和尿路畸形的发生风险,同时也会对子代早期和远期肾功能造成一定损害。此外,该文从氧化应激、肾脏发育关键信号通路及表观遗传改变等方面对母体糖尿病干扰子代肾脏发育过程及其中的分子机制的研究进展进行综述。

Maternal diabetes not only affects the mother′s own health but also has a significant influence on offspring.Adverse prenatal and intrauterine condition can influence fetal kidney development,which may increase the risk of kidney disease in the adulthood.This article reveiws the impact of maternal diabetes on kidney structure and function.Maternal diabetes can increase the risk of congenital anomalies of the kidney and urinary tract(CAKUT)and impair early and long-term renal function of offspring.In addition,this article reveiws the research progress of the potential mechanisms of how maternal diabetes affects kidney development including oxidative stress,key signal pathway changes of kidney development and epigenetic changes.