顺铂诱导耳毒性的发生机制及预防措施研究进展

Progress in the mechanisms and preventive measures of cisplatin-induced ototoxicity

顺铂是一种广谱且高效的化疗药物,其治疗效果存在剂量依赖性,高剂量治疗受到耳毒性、肾毒性以及神经毒性的限制。耳毒性是顺铂化疗后常见且严重的并发症,极大地影响肿瘤患者的生活质量。目前尚无食品药物管理局批准预防顺铂化疗后听力损失的耳保护药物。近年来,国内外关于顺铂诱导耳毒性的研究揭示了许多新的发生机制和治疗靶点,许多候选耳保护药物显示出了良好的听力保护作用。并且新型的局部给药方式也不断优化,有望进一步转化为临床应用。

Cisplatin is a broad-spectrum and highly effective chemotherapeutic agent,with a dose-dependent therapeutic effect.Unfortunately,high-does therapy is limited by ototoxicity,nephrotoxicity and neurotoxicity.Ototoxicity is a common and serious complication after cisplatin chemotherapy,which has greatly debilitating effect on patients′quality of life.Currently,there are no FDA-approved drugs available to prevent cisplatin-induced hearing loss.In recent years,domestic and international studies on cisplatin-induced ototoxicity have revealed many new mechanisms and therapeutic targets.Many candidate agents have shown good hearing protection.Moreover,local drug delivery methods are being optimized,promising for further translations to clinical applications.