摘要
肠道菌群代谢物与疾病间的相互作用及机制是研究的热点。脱氧胆酸是肠道菌群代谢物,是人体肠道较丰富的次级胆汁酸之一,被证明与多种疾病相关,但机制不清。脱氧胆酸水平的失调与肠道菌群失调和高脂饮食相关,而这种失调会导致机体产生一系列免疫及炎症反应。该文从脱氧胆酸与儿童消化系统疾病,如非酒精性脂肪性肝病、炎症性肠病和肠易激综合征的相互作用出发,探讨其相关机制,为进一步研究肠道菌群代谢物脱氧胆酸对机体的影响阐明方向。
It is the hotspot that studying the interplay and mechanism between intestinal flora metabolites and diseases.Deoxycholic acid,one of the intestinal flora metabolites,is one of the most abundant secondary bile acids in human intestinal tract,which is corelated with many diseases,while the mechanisms remain unclear.The imbalance of deoxycholic acid is connected with the intestinal flora disorder and high fat diet,which could result in several immunoreaction and inflammatory reaction.In this review,the interaction between deoxycholic acid and digestive diseases in children,such as non-alcoholic fatty liver disease,inflammatory bowel disease and irritable bowel syndrome,is discussed to explore their related mechanism,so as to clarify the direction of further study on the influence of intestinal microbiota metabolites deoxycholic acid on the human body.
作者
梁彩红(综述)
黄永坤(审校)
Liang Caihong;Huang Yongkun(Department of Pediatrics,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)
出处
《国际儿科学杂志》
2023年第4期267-271,共5页
International Journal of Pediatrics
基金
国家自然科学基金(81960102)。
关键词
肠道菌群代谢物
脱氧胆酸
非酒精性脂肪性肝病
炎症性肠病
肠易激综合征
Intestinal flora metabolites
Deoxycholic acid
Non-alcoholic fatty liver disease
Inflammatory bowel disease
Irritable bowel syndrome
