Miro1蛋白在帕金森病发病中的作用

The role of Miro1 protein in the pathogenesis of Parkinson’s disease

帕金森病(PD)的关键调控机制如线粒体功能障碍、α-突触核蛋白异常聚集等与受损的细胞内钙稳态和线粒体动力学有关。调控线粒体稳态和细胞凋亡的蛋白Miro1可通过影响线粒体自噬、钙离子失衡、线粒体转运等,最终导致神经细胞变性死亡。Miro1蛋白缺陷可能是PD病理生理机制的共同通路。因此,Miro1蛋白在PD发病机制中起关键作用。本文对Miro1蛋白参与调控PD发病进行综述。

In the pathogenesis of Parkinson’s disease(PD),the key regulatory mechanisms such as mitochondrial dysfunction and abnormalα-synuclein aggregation are linked to impaired intracellular calcium homeostasis and mitochondrial dynamics.Miro1,a protein that regulated mitochondrial homeostasis and apoptosis,led to degenerative neuronal cell death by affecting mitochondrial autophagy,calcium imbalance,and mitochondrial transport.Miro1 protein deficiency may be a common pathway in the pathophysiological mechanisms of PD.Therefore,Miro1 protein played a key role in the pathogenesis of PD.This paper reviewed the involvement of Miro1 protein in regulating PD pathogenesis.