磁适配体生物传感器

Magnetic Aptamer Biosensors

磁珠(magnetic beads,MBs)是具有磁性的微小球形颗粒,在将分析物从复杂基质中分离出来以及固定配体等方面发挥关键作用。为了获得不同的识别及信号输出性能,MBs可以与各种反应基团进行功能化并发挥相应作用。对磁珠的性质、制备方法、功能化改性与搭载适配体的应用等方面进行了全面综述,总结了磁生物传感器所表现出的准确性、及时性、便携性、低成本,及在痕量水平上的信号放大等优势。最后,提出了磁珠潜在的应用挑战和未来方向。

Magnetic beads(MBs)are small spherical particles with magnetism,which plays a key role in separating analytes from complex matrices and fixing ligands.In order to obtain different recognition and signal output performance,MBs can be functionalized with various reaction groups to play a corresponding role.In this review,we reviewed the properties,preparation methods,functional modification and application of carrying adapters of magnetic beads.The advantages of magnetic biosensors,such as the accuracy,timeliness,portability and low cost as well as the signal amplification at the trace level,were summarized.Finally,the potential application challenges and future directions of magnetic beads were proposed.