氢气与线粒体作用关系的研究进展

Research Progress on the Relationship Between Hydrogen and Mitochondria

氢气是一种无色无味的惰性气体,随着氢分子医学的发展,研究人员发现氢气对多种疾病都有很好的预防和治疗效果,但有关氢干预治疗性效应的作用机制及其具体靶点尚不明确,这些问题都等待着人们深入探索。研究发现,氢气的抗氧化、抗凋亡、调节代谢等都与线粒体有关,同时线粒体还与氢化酶和氢化酶体具有一定程度的同源性,这些发现为氢分子作用机制的研究奠定了基础。对目前已知的与线粒体相关的氢分子作用机制进行了总结,讨论了氢代谢与线粒体之间的关系,以期为后续研究氢分子生物学效应的作用机制提供参考。

Hydrogen is a colorless and tasteless inert gas.With the development of hydrogen molecular medicine,researchers have found that hydrogen has a good preventive and therapeutic effect on a variety of diseases,but the mechanism and specific targets of hydrogen intervention for therapeutic effect are not clear.It has been found that the antioxidant,anti apoptotic,metabolic regulation and other effect of hydrogen are related to mitochondria,and mitochondria also has a certain degree of homology with hydrogenase and hydrogenosome.These foundings have laid the foundation for the research on the mechanism of hydrogen.In this review,we summarized the currently known mechanisms of hydrogen related to mitochondria,and discussed the relationship between hydrogen metabolism and mitochondria,in order to provide reference for the subsequent research on the mechanism of molecular biological effects of hydrogen.