合成生物学在治疗代谢性疾病中的研究进展

Advances in Synthetic Biology on the Treatment of Metabolic Diseases

代谢性疾病(metabolicdisease,MD)一直以来是健康领域面临的重大挑战,其发生发展与宿主的代谢和免疫存在密切联系。近年来基于肠道菌群的治疗策略层出不穷,特别是利用合成生物学改造的微生物,对于代谢性疾病的预防和治疗展现出良好的应用潜力。通过对微生物基因路线和代谢途径进行合理设计和改造,可以实现目标物质的稳定输出和精准投递,进而治疗疾病。着重综述了合成生物学在代谢性疾病预防和治疗中的研究进展,以期为改善和治疗代谢性疾病提供新的思路和方法。

Metabolic diseases(MD)has been a major challenge in health care and its occurrence and development are closely related to the metabolism and immunity.In recent years,treatment strategies based on gut microbiota have incompleted,especially the microorganisms modified by synthetic biology,which show good potential application for the prevention and treatment of MD.To cure diseases,the design and transformation of microbial gene routes and metabolic pathways can achieve stable output and accurate of target substances.This review focused on the research progress of synthetic biology in the prevention and treatment of MD,with a view to providing new ideas and methods for improving and treating MD.