黏蛋白在肿瘤免疫治疗中的研究进展

Research Progress of Mucin in Tumor Immunotherapy

黏蛋白是一类主要由黏多糖组成的高分子量糖蛋白,其主要分布在人体的各种管腔内表面,对上皮细胞起到保护和润滑作用。多项研究表明,黏蛋白在肿瘤的发生发展中扮演着重要角色,因此,部分黏蛋白被确定为肿瘤标志物,成为很有前景的肿瘤治疗靶点。综述了目前以黏蛋白为靶点的肿瘤治疗方案,包括小分子抑制剂、抗体疗法、疫苗等方面,以期为临床肿瘤诊治方法的发展与优化提供理论参考。

The mucin(MUC)family is a group of highly glycosylated macromolecules,which is mainly distributed in the body of various lumen surface,playing a role in protecting and lubricating epithelial cells.Many studies have shown that mucins play an important role in the occurrence and development of tumors.Therefore,some mucins have been identified as tumor markers and become promising tumor therapeutic targets.This paper reviewed the current mucin-targeted tumor therapy,including small molecule inhibitors,antibody therapy,vaccines,etc,hoping to provide theoretical reference for the development and optimization of clinical tumor diagnosis and treatment methods.