补阳还五汤联合艾灸治疗老年晚期肺癌疗效观察

Observation on therapeutic effect of Buyang Huanwu Decoction combined with moxibustion on advanced lung cancer in the elderly

目的观察补阳还五汤联合艾灸治疗老年晚期肺癌的疗效。方法将70例符合纳入标准的患者随机分为治疗组和对照组各35例,均给予抗肿瘤及对症支持治疗,治疗组加补阳还五汤及温和灸,均治疗6周。对比2组中医证候疗效及治疗前后中医证候评分、外周血T淋巴细胞亚群、肺癌患者生存质量量表(FACT-L)评分、凝血及血小板指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、D-二聚体(D-D)、血小板(PLT)]、安全性。结果治疗后治疗组中医证候积分为(17.14±2.59)分低于对照组(21.14±2.84)分(P<0.05);治疗组中医证候总有效率(80.0%)优于对照组(51.4%),差异有统计学意义(P<0.05)。治疗后,治疗组CD8+T淋巴细胞比例较治疗前及对照组低,其余各项指标均较治疗前及对照组高,差异均有统计学意义(P<0.05);而对照组各项指标治疗前后差异无统计学意义(P>0.05)。治疗后,治疗组除社会/家庭情况评分外,其余各项评分均较治疗前及对照组高(P<0.05);而对照组各项评分治疗前后比较差异均无统计学意义(P>0.05)。治疗后,治疗组APTT、PT延长,较治疗前及对照组高(P<0.05);FIB、PLT、D-D较治疗前及对照组低(P<0.05);而对照组上述指标治疗前后比较差异均无统计学意义(P>0.05)。结论补阳还五汤联合温和灸能够调节机体的免疫功能,缓解高凝状态;改善气虚血瘀证候,提高生存质量。

Objective To observe the efficacy of Buyang Huanwu Decoction combined with moxibustion in the treatment of advanced lung cancer in the elderly.Methods 70 patients who met the inclusive criteria were randomly divided into treatment group and control group,with 35 patients in each group.All patients were treated with anti-tumor and symptomatic support.The treatment group was treated with Buyang Huanwu Decoction and mild moxibustion for 6 weeks.The efficacy of the two groups and the scores before and after treatment with traditional Chinese medicine syndromes,T-lymphocyte subsets in peripheral blood,quality of life scale scores of lung cancer patients(FACT-L),coagulation and platelet indexes(prothrombin time,PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),D-dimer(D-D),platelet(PLT)and safety were compared.Results After treatment,the Traditional Chinese medicine syndrome score in the treatment group was(17.14±2.59)points,which was lower than that in the control group(21.14±2.84)points(P<0.05),the total effective rate of the treatment group(80.0%)was better than that of the control group(51.4%),with a statistically significant difference(P<0.05).After treatment,the ratio of CD8+T lymphocytes in the treatment group was lower than those in the same group before treatment and the control group after treatment,and the other indexes were higher than those in the same group before treatment and the control group after treatment,with the difference statistically significant(P<0.05).There was no significant difference in the control group before and after treatment(P>0.05).After treatment,except for social/family situation scores,the other scores in the treatment group were higher than those in the treatment group before treatment and the control group after treatment(P<0.05),while there was no significant difference in the scores of the control group before and after treatment(P>0.05).After treatment,APTT and PT in the treatment group were prolonged,which were higher than those in the same group before treatment and the control group after treatment(P<0.05),FIB,PLT,and D-D were lower in the treatment group than those in the same group before treatment and the control group after treatment(P<0.05).There was no significant difference in the above indexes before and after treatment in the control group(P>0.05).Conclusion Buyang Huanwu Decoction combined with mild moxibustion can regulate the body's immune function,relieve hypercoagulable state,improve Qi-deficiency and blood stasis syndrome,andenhance the quality of life.