强脉冲光联合A型肉毒毒素治疗玫瑰痤疮疗效观察

Efficacy of Intense Pulsed Light Combined with Botulinum Toxin Type A in the Treatment of Rosacea

目的:研究强脉冲光联合A型肉毒毒素治疗玫瑰痤疮的疗效及对患者皮肤屏障功能、生活质量的影响。方法:收集2020年3月-2021年12月笔者医院收治的124例玫瑰痤疮患者以随机数字表法分组,对照1组(41例)接受A型肉毒毒素治疗,对照2组(42例)接受强脉冲光治疗,观察组(41例)接受强脉冲光联合A型肉毒毒素治疗。记录疗效、不良反应、1年复发情况、治疗前后症状积分、皮肤屏障功能、皮肤病生活质量指数问卷(Dermatology life quality index,DLQI)。结果:观察组的有效率高于对照1组、对照2组(P<0.05)。治疗后,观察组的症状积分、皮肤屏障功能(经皮水分丢失量、皮肤含水量、皮脂含量)及DLQI均优于对照1组和对照2组(P<0.05),对照1组与对照2组的症状积分、皮肤屏障功能、DLQI差异无统计学差异(P>0.05)。三组不良反应差异无统计学差异(P>0.05)。观察组的1年复发率低于对照1组、对照2组(P<0.05)。结论:强脉冲光联合A型肉毒毒素治疗玫瑰痤疮能够提高疗效,改善患者皮肤屏障功能和DLQI。

Objective To research the efficacy of intense pulsed light combined with botulinum toxin type A in the treatment of rosacea and its effect on skin barrier function and quality of life.Methods A total of 124 patients with rosacea admitted to the author's hospital from March 2020 to December 2021 were collected and divided into 3 groups by random number table method.The control group 1(n=41)received botulinum toxin type A,the control group 2(n=42)received intense pulsed light and the observation group(n=41)received intense pulsed light combined with botulinum toxin type A.The efficacy,adverse reactions,1-year recurrence,the symptom score,skin barrier function,dermatology life quality index(DLQI)before and after treatment was evaluated and compared within 3 groups.Results The effective rate of the observation group was higher than that of control group 1 and control group 2(P<0.05).After treatment,the symptom scores,skin barrier function(transcutaneous water loss,skin moisture content,sebum content)and DLQI of the observation group were improved than those of the control group 1 and control group 2(P<0.05).There was no statistical difference in adverse reactions and 1-year recurrence in 3groups(P>0.05).The 1-year recurrence of the observation group was lower than that of control group 1 and control group 2(P<0.05).Conclusion The intense pulsed light combined with botulinum toxin type A can be used in treatment of rosacea by improving skin barrier function and DLQI.