microRNA-124与疾病的研究进展

Advances in Research on microRNA124 in Diseases

microRNA(miRNA)是一类长度为20~24个核苷酸的非编码单链RNA,被称为转录后调控因子.miRNA是在转录后调控其靶基因发挥作用.miRNA表达的改变在多种疾病的发生发展过程中发挥重要的调控作用.其中,microRNA124(miR-124)是目前的研究热点之一,它在多种肿瘤中低表达,并在细胞增殖、侵袭转移及凋亡等方面发挥重要的抑癌作用,密切参与恶性肿瘤的发生、发展和预后.文章综述了非恶性疾病与恶性疾病中miR-124的作用机制,为疾病的诊断与治疗提供理论证据.

microRNA(miRNA)is a kind of non-coding single-stranded RNA with a length of 20~24 nucleotides,which is called post-transcriptional regulatory factor.miRNA regulates its target genes after transcription.The changes of miRNA expression play important regulatory roles in the occurrence and development of many diseases.microRNA 124(miR-124)is one of the research hotspots at present.It is lowly expressed in many types of tumors,and has played important roles in suppressing tumor growth and metastasis through regulation of cell proliferation,invasion and apoptosis.It has closely participated in the occurrence,development and prognosis of malignant tumors.This review aims to make a summary of the mechanism of miR-124 in non-malignant and malignant diseases to provide theoretical evidence for their diagnosis and treatment.