中药引药上行的作用机制及其脑靶向制剂研究进展

Research progress on mechanism of uplink of traditional Chinese medicine and its brain targeting preparations

引经药是在中药归经理论指导下,引导诸药直达病所,起“向导”作用的药物。冰片、石菖蒲、麝香、苏合香和安息香等芳香开窍类中药具有引药上行之功,可以改善血脑屏障的通透性,并通过引药上行作用促进其他药物透过血脑屏障,提高其他药物的生物利用度和脑组织分布。通过对近年来冰片、石菖蒲等引经药调节血脑屏障通透性及作用机制,芳香开窍类引经药与现代制剂结合构建新型脑靶向递药系统的研究进行综述,以期丰富引经药的科学内涵并为新型脑靶向药物递送系统的设计提供新策略。

Under the guidance of theory of traditional Chinese medicine to return to the meridian,the drugs that introduce meridian are the drugs that guide all kinds of drugs to place of disease.Bingpian(Borneolum Syntheticum),Shichangpu(Acori Tatarinowii Rhizoma),Shexiang(Moschus),Suhexiang(Styrax),Anxixiang(Benzoinum)and other aromatic herbal medicines have the function of upward priming,which can improve permeability of blood-brain barrier,promote other drugs to penetrate blood-brain barrier through upward priming,and improve bioavailability of other drugs and brain tissue distribution.In this paper,the recent studies on regulation of blood-brain barrier permeability and its mechanism of action by borneol,calamus and other meridian induction drugs,and the construction of a new type of brain targeted drug delivery system by combining aromatically-induced meridian induction drugs with modern preparations were reviewed to enrich the scientific connotation of meridian induction drugs and provide a new strategy for the design of a new type of brain targeted drug delivery system.