滇重楼药材的研究进展及其质量标志物(Q-Marker)预测分析

Research progress and quality marker prediction analysis of Paris polyphylla var.yunnanensis

对滇重楼Paris polyphylla var.yunnanensis化学成分、药理作用、毒性评价及构效关系进行系统综述,依据中药质量标志物(quality marker,Q-Marker)理论,结合滇重楼中化学成分与其功效主治、药性、可测性、质量传递与溯源等方面的关联性分析滇重楼潜在的Q-Marker。在功效与滇重楼中化学成分关联中发现,滇重楼作用于肝、肾、肺、血、胎盘等组织,干预癌症、高血压、癫痫、肝损伤、关节炎等疾病;结合中药Q-Marker理论指导原则,揭示了重楼皂苷Ⅰ、Ⅱ、Ⅲ、Ⅵ、Ⅶ、H,纤细薯蓣皂苷,蜕皮激素、多糖、黄酮等可作为滇重楼功效相关的Q-Marker,为制定更加科学全面的滇重楼质量控制标准和临床合理应用提供理论依据。

In this paper,the chemical constituents,pharmacological effects,toxicity evaluation and structure-activity relationship of Paris polyphylla Smith var.yunnanensis are summarized.Based on the quality marker(Q-Marker)theory of traditional Chinese medicine,the potential Q-Marker of P.polyphylla Smith var.yunnanensis was analyzed in combination with the chemical components and their efficacy and indications,medicinal properties,measurability,mass transfer and traceability.In the correlation between the efficacy and the chemical components,it was found that P.polyphylla var.yunnanensis acts on the liver,kidney,lung,blood,placenta and other tissues,intervening in cancer,hypertension,epilepsy,liver damage,arthritis and other diseases.Combining with the guiding principles of traditional Chinese medicine Q-Marker theory,it was revealed that polyphyllins I,II,III,VI,VII,H,gracillin,ecdysone,polysaccharide,flavonoid,etc.can be used as Q-Marker,which provides a theoretical basis for formulating more scientific and comprehensive quality control standards of P.polyphylla var.yunnanensis and rational clinical application.