慢性术后疼痛机制的研究进展

Research advances in the mechanism of chronic post‑surgical pain

慢性术后疼痛(chronic post⁃surgical pain,CPSP)是干扰患者术后日常活动和影响患者身体基本机能恢复的一类疼痛综合征,并带来沉重的社会经济负担。CPSP的发病机制十分复杂,尚不明确,给疾病的治疗带来困难。目前的研究支持CPSP受到遗传、社会心理、情感、认知等方面的影响,并且与复杂的神经系统调制有关。文章简要介绍CPSP的定义和流行病学,从遗传的疼痛易感性出发,结合表观遗传因素、肠道微生物、环境以及神经调制系统的相互作用,重点阐述CPSP的发病机制,旨在为基础研究提供新思路、为临床实践提供参考。

Chronic post⁃surgical pain(CPSP)represents a pain syndrome that interferes with postoperative daily activities and affects recovery of body functions,posing a heavy social and economic burden.Its pathogenesis is complex and unclear,which causes difficulties in treatment.Current research suggests that CPSP is influenced by genetic,psychosocial,emotional,and cognitive factors and is associated with complex neurological modulation.This review briefly introduces the definition and epidemiology of CPSP.Based on the genetic susceptibility and the interaction of epigenetic factors,gut microbes,environment,and neuro⁃modulatory system,we mainly addressed the pathogenesis of CPSP.The aim of this review is to provide new ideas for basic medical research and clinical prac⁃tice.