炎症因子与双相障碍脑影像特征的关联性研究进展

Research progress on the association between inflammatory cytokines and neuroimaging characteristics of bipolar disorder

双相障碍的病因及发病机制复杂。近年来,神经免疫学与神经影像学方面的研究进展与突破,对双相障碍的临床诊断与治疗产生了重大的影响。将炎症因子与脑影像特征交叉分析,或许更能揭示双相障碍的疾病进程及其机制,探索新的治疗靶点。本文综合双相障碍炎症因子与神经影像特征之间关联的研究,同时进行归纳总结,并对未来的研究方向进行展望。

The pathogeny and pathogenesis of bipolar disorder(BD)are complex.Recently,the progress and breakthrough in neuroimmunology and neuroimaging research have significantly affected the diagnosis and treatment of bipolar disorder.Cross-analysis of inflammatory cytokines and brain imaging features may better reveal the pathogenesis of BD and explore new interventional targets.This review summarises and analyses the studies that show the association between inflammatory cytokines and neuroimaging features in patients with bipolar disorder and proposes possible future research directions.