从脂质代谢途径探讨中药雷公藤“物-效/毒-靶”关联性的研究现状与展望

Component-effect/toxicity-target correlations of Tripterygium wilfordii in terms of lipid metabolism

目的从机体脂质代谢角度出发,分析归纳中药雷公藤效/毒相关物质基础的作用途径,探讨其“物-效/毒-靶”关联性,以寻找雷公藤药效和毒性成分的创新研究方法与视角。方法收集并梳理近年来雷公藤制剂及其活性物质在脂质代谢调控方面的相关文献,在药性理论指导上,结合临床用药实际情况与实验研究结果,构建“物-效/毒-靶”关联性的分析模式。结果雷公藤制剂及活性物质通过参与调控脂肪酸代谢、磷脂类代谢以及固醇类代谢在内的多个关键脂质代谢环节发挥药效作用,但同时也可诱发脂质过氧化物堆积、磷脂类代谢紊乱、胆汁酸淤积等负面途径的致毒反应。结论从脂肪代谢途径解析“物-效/毒-靶”关联性有利于指导临床合理用药。

Objective To analyze the lipid metabolic pathways related to the efficacy and/or toxicity of Tripterygium wilfordii’s and to explore the component-effect/toxicity-target correlations.Methods Recent literature on the regulation of lipid metabolism by Tripterygium wilfordii preparations and its active components was collected and reviewed.An analytical model for component-effect/toxicity-target correlations was established based on theories of pharmacology,clinical use and experimental research.Results Tripterygium wilfordii preparations and its active components proved to exert therapeutic effects by regulating multiple key processes of lipid metabolism,including fatty acid metabolism,phospholipid metabolism and steroid metabolism while inducing various toxic effects due to lipid peroxidation,phospholipid metabolism disorders and bile acid accumulation.Conclusion The analysis of the component-effect/toxicity-target correlations from perspective of lipid metabolism pathways can help to better understand and evaluate its effectiveness and safety,which will facilitate rational medications in clinical practice.