沙库巴曲缬沙坦治疗尿毒症维持性血液透析合并心力衰竭患者疗效

Therapeutic effect of sarcubatrivalsartan on uremic patients with maintenance hemodialysis and heart failure

目的研究沙库巴曲缬沙坦治疗尿毒症维持性血液透析合并心力衰竭患者疗效.方法选取2020年2月-2022年5月中山市人民医院南朗分院接诊的60例MHD合并心力衰竭患者,对患者治疗前及治疗后临床资料、实验室指标、超声心动图等资料进行分析.结果经3个月治疗后,60例接受治疗的患者治疗总有效率为98.33%,治疗前后NYHA分级患者比例分布差异具有统计学意义(P<0.05);SBP、DBP较治疗前出现显著下降,差异具有统计学意义(P<0.05);NT-proBNP与治疗前相比显著降低,差异具有统计学意义(P<0.05),Scr、K、Na、Ca、P、HGB、PTH等数值变化差异不显著,无统计学意义(P>0.05);LVPWTd、LVEF、LVMI治疗前后数值变化差异明显,有统计学意义(P<0.05),IVSTD、LVDd及LVSd前后变化差异不明显,无统计学意义(P>0.05).结论使用沙库巴曲缬沙坦对尿毒症维持性血液透析合并心力衰竭患者进行治疗,能有效改善患者心脏功能,减轻左心室肥厚症状,逆转左心室重构,降低患者血压,且具有较高的安全性,值得在临床中推广.

Objective To study the therapeutic effect of sarcubatrixartan on uremic patients with maintenance hemodialysis and heart failure.Methods 60 patients with MHD complicated with heart failure admitted to our hospital from February 2020 to May 2022 were selected,and the clinical data,laboratory indicators,echocardiography and other data of the patients before and after treamt ent were analyzed.Results After 3 months of treatment,the total effective rate of 60 paietnts receiving treatment was 98.33%,and the proportion of patients with NYHA classification before and after treatmen twas significantly different P(<0.05);SBP and DBP decreased significantly compared with those before treatmentP(<0.05);NT-proBNP was significantly lower than that before treatment,and the difference was statistically significant(P<0.05).The change of Scr,K,Na,Ca,P,HGB,PTH and other values was not statistically significant(P>0.05);the changes of,LVPWTd,LVEF and LVMI before and after treatment were significantly different,with statistical significance(P<0.05).The changes of IVSTD LVDd and LVSd before and after treatment were not significantly different,with no statistical significance(P>0.05).Conclusion The treatment of patients with uremic maintenance hemodialysis combined with heart failure with sarcubatrixartan can effectively improve the cardiac function of patients,alleviate the symptoms of left ventricular hypertrophy,reverse left ventricular remodeling,and lower blood pressure,and has high safety,which is worth promoting in clinical practice.