改良宫颈环扎联合缩宫抑制疗法对多胎孕产妇妊娠期宫颈机能不全的治疗效果

The Therapeutic Effect of Improved Cervical Cerclage Combined with Uterine Contraction Inhibition Therapy in the Treatment of Cervical Dysfunction during Pregnancy in Multiple Pregnancy Women

目的:研究改良宫颈环扎联合缩宫抑制疗法对多胎孕产妇妊娠期宫颈机能不全的治疗效果。方法:选取2021年9月-2022年3月在仙桃市妇幼保健院就诊的80例妊娠期宫颈机能不全多胎孕产妇,按照治疗方法分为缩宫抑制组40例,环扎联合组40例。缩宫抑制组给予缩宫抑制疗法,环扎联合组采用改良宫颈环扎联合缩宫抑制疗法;采用溴甲酚绿显色法检测氧化应激反应总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)变化水平;采用酶联吸附法检测松弛素、抗核抗体(ANA)、抗心磷脂抗体(ACA);统计临床疗效;并发症发生率;不良妊娠结局。结果:与缩宫抑制组相比,环扎联合组松弛素、ANA、ACA水平均显著更低,差异均有统计学意义(P<0.05),与缩宫抑制组相比,环扎联合组T-AOC、SOD水平均显著更高,差异有统计学意义(P<0.05),与缩宫抑制组相比,环扎联合组治疗总有效率较高,差异有统计学意义(P<0.05)。与缩宫抑制组相比,环扎联合组并发症及不良妊娠结局发生率略低,差异均有统计学意义(P<0.05)。结论:改良宫颈环扎联合缩宫抑制疗法可有效降低多胎孕产妇妊娠期宫颈机能不全患者手术并发症,降低术后不良妊娠发生情况,促进术后快速恢复。

Objective:To study the treatment effect of modified cervical cerclage combined with uterine contraction inhibition therapy on cervical dysfunction during pregnancy in multiple pregnancy women.Method:A total of 80 cases of multiple pregnant women with cervical dysfunction during pregnancy in Xiantao Maternal and Child Health Care Hospital from September 2021 to March 2022 were selected.According to the treatment method,they were divided into the uterine contraction inhibition group(n=40)and the cerclage combined group(n=40).The uterine contraction inhibition group was given uterine contraction inhibition therapy,and the cerclage combined group was given modified cervical cerclage combined with uterine contraction inhibition therapy.Total antioxidant capacity(T-AOC)in oxidative stress response,superoxide dismutase(SOD),relaxin,anti-nuclear antibody(ANA)and anti-cardiolipin antibody(ACA)were examined by bromocresol green chromogenic assay;clinical efficacy of patients,complication rate and adverse pregnancy outcomes were counted.Result:Compared with the uterine contraction inhibition group,the levels of relaxin,ANA and ACA in the cerclage combined group were significantly lower,the differences were statistically significant(P<0.05).Compared with the uterine contraction inhibition group,the levels of T-AOC and SOD in the cerclage combined group were significantly higher,and the differences were statistically significant(P<0.05),and the total effective rate in the cerclage combined group was higher than that in the uterine contraction inhibition group,the difference was statistically significant(P<0.05).Compared with the contraction inhibition group,the incidences of complications and adverse pregnancy outcomes in the cerclage combined group were slightly lower,with statistical significance(P<0.05).Conclusion:Improved cervical cerclage combined with uterine contraction inhibition therapy can effectively reduce the surgical complications of multiple pregnant maternal patients with cervical insufficiency during pregnancy,reduce the occurrence of postoperative adverse pregnancy,and promote the rapid postoperative recovery.