阿托伐他汀钙强化治疗对老年冠心病合并阵发性心房颤动患者左心功能、hs-CRP及房颤发作次数的影响

Effects of Intensive Atorvastatin Calcium Therapy on Left Ventricular Function,hs-CRP and the Frequency of Atrial Fibrillation in Elderly Patients with Coronary Heart Disease Complicated with Paroxysmal Atrial Fibrillation

目的:分析阿托伐他汀钙强化治疗对老年冠心病合并阵发性心房颤动患者左心功能、超敏C反应蛋白(hs-CRP)及心房颤动发作次数的影响。方法:将昆明市中医医院2021年1月-2022年1月收治的70例老年冠心病合并阵发性心房颤动患者作为研究对象,按照随机数字表法,将患者分为对照组与研究组,各35例。两组患者均口服阿托伐他汀钙进行治疗,其中对照组给予常规剂量(40 mg/d),研究组给予强化剂量(80 mg/d)。比较两组治疗前和治疗后房颤发作次数、左室射血分数(LVEF)、左心房内径(LAD)及hs-CRP水平的差异。结果:治疗后,两组心房颤动发作次数均少于治疗前,且研究组心房颤动发作次数较对照组少(P<0.05)。相比治疗前,两组治疗后LAD显著下降,LVEF显著增高,且研究组LAD较对照组低,LVEF较对照组高(P<0.05)。与治疗前相比,两组治疗后hs-CRP水平显著下降,且研究组hs-CRP水平较对照组低(P<0.05)。结论:应用阿托伐他汀钙治疗可有效改善老年冠心病合并阵发性心房颤动患者左心房功能,减少心房颤动发作次数,减轻临床症状,同时具有减轻炎症反应的作用,其中强化剂量治疗的效果更优,因此具有良好的临床应用前景。

Objective:To analyze the effect of intensive Atorvastatin Calcium therapy on left ventricular function,hypersensitive C reactive protein(hs-CRP)and the frequency of atrial fibrillation in elderly patients with coronary heart disease complicated with paroxysmal atrial fibrillation.Method:A total of 70 elderly patients with coronary heart disease complicated with paroxysmal atrial fibrillation admitted to Kunming Traditional Chinese Medicine Hospital from January 2021 to January 2022 were selected as the research subjects.According to the random number table method,the patients were divided into the control group and the research group,35 cases in each group.Patients in both groups were treated with Atorvastatin Calcium orally,in which the control group was given the conventional dose(40 mg/d)and the research group was given the intensive dose(80 mg/d).The differences of the frequency of atrial fibrillation,left ventricular ejection fraction(LVEF),left atrial diameter(LAD)and hs-CRP levels were compared between the two groups before and after treatment.Result:After treatment,the frequency of atrial fibrillation in both groups were less than that before treatment,and the frequency of atrial fibrillation in the research group was less than that in the control group(P<0.05).Compared with before treatment,LAD decreased significantly and LVEF increased significantly in the two groups after treatment,and LAD in the research group was lower than that in the control group,and LVEF was higher than that in the control group(P<0.05).Compared with before treatment,the levels of hs-CRP in the two groups decreased significantly after treatment,and the level of hs-CRP in the research group was lower than that in the control group(P<0.05).Conclusion:Application of Atorvastatin Calcium therapy can effectively improve the left atrial function of elderly patients with coronary heart disease complicated with paroxysmal atrial fibrillation,reduce the frequency of atrial fibrillation,and reduce clinical symptoms.At the same time,it has the effect of reducing inflammatory response.The effect of intensive dose therapy is better,so it has a good prospect for clinical application.