丹参酮ⅡA磺酸钠联合单硝酸异山梨酯治疗冠心病心绞痛的效果及安全性

Efficacy and Safety of Sulfotanshinone Sodium Combined with Isosorbide Mononitrate in the Treatment of Coronary Heart Disease and Angina Pectoris

目的:探讨丹参酮ⅡA磺酸钠联合单硝酸异山梨酯治疗冠心病心绞痛的效果及安全性。方法:选取2017年1月-2021年12月于九江市柴桑区人民医院住院的86例冠心病心绞痛患者,按照随机数字表法将其分为对照组和病例组,各43例。对照组给予单硝酸异山梨酯,病例组在对照组基础上加用给予丹参酮ⅡA磺酸钠。比较两组血清炎症因子、血液流变学、血脂、氧化应激和血管内皮功能的影响及住院期间主要不良事件(MACE)发生情况。结果:治疗后病例组总有效率为97.67%,高于对照组的86.05%,差异有统计学意义(P<0.05)。病例组MACE发生率为9.30%,低于对照组的18.60%,差异无统计学意义(χ^(2)=1.550,P=0.213)。两组患者治疗后超氧化物歧化酶(SOD)、一氧化氮(NO)、高密度脂蛋白胆固醇(HDL-C)水平均较治疗前升高,丙二醛(MDA)、血清内皮素(ET-1)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、全血低切黏度、全血高切黏度、红细胞压积(HCT)、血浆黏度、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均较治疗前降低,且病例组SOD、NO、HDL-C水平均高于对照组,MDA、ET-1、IL-6、IL-8、TNF-α、CRP、全血低切黏度、全血高切黏度、HCT、血浆黏度、TC、TG、LDL-C水平均低于对照组(P<0.05)。结论:丹参酮ⅡA磺酸钠联合单硝酸异山梨酯对冠心病心绞痛患者可以改善血液流变学,调节血脂水平、氧化应激和血管内皮功能,降低炎症反应程度,临床疗效显著。

Objective:To investigate the clinical efficacy and safety of Sulfotanshinone Sodium combined with Isosorbide Mononitrate in the treatment of coronary heart disease and angina pectoris.Method:A total of 86 patients with angina pectoris of coronary heart disease hospitalized in People's Hospital of Chaisang District of Jiujiang City from January 2017 to December 2021 were selected,they were divided into control group and case group according to random number table method,with 43 cases in each group.The control group was given Isosorbide Mononitrate,and the case group was given Sulfotanshinone Sodium on the basis of control group.The effect of serum inflammatory factors,hemorheology,blood lipids,oxidative stress and vascular endothelial function and the occurrence of major adverse events(MACE)during hospitalization were compared between the two groups.Result:After treatment,the total effective rate of the case group was 97.67%,which was higher than 86.05%of the control group,the difference was statistically significant(P<0.05).The incidence of MACE of the case group was 9.30%,which was lower than 18.60%of the control group,the difference was not statistically significant(χ^(2)=1.550,P=0.213).After treatment,the levels of superoxide dismutase(SOD),nitric oxide(NO)and high-density lipoprotein cholesterol(HDL-C)of both group were higher than those before treatment,malondialdehyde(MDA),serum endothelin(ET-1),interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α),C reactive protein(CRP),whole blood low tangential viscosity,whole blood high tangential viscosity,hematocrit(HCT),plasma viscosity,total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)levels were lower than those before treatment,and SOD,NO and HDL-C levels of the case group were higher than those of the control group,MDA,ET-1,IL-6,IL-8,TNF-α,CRP,whole blood low tangency viscosity,whole blood high tangency viscosity,HCT,plasma viscosity,TC,TG,LDL-C levels were lower than those of control group(P<0.05).Conclusion:Sulfotanshinone Sodium combined with Isosorbide Mononitrate can improve hemorheology,regulate blood lipid level,oxidative stress and vascular endothelial function,reduce the degree of inflammatory reaction in patients with coronary heart disease and angina pectoris,the clinical effect is significant.