重组人脑利钠肽在中老年心力衰竭患者中的疗效及对神经激素、心功能的影响

Effect of Recombinant Human Brain Natriuretic Peptide in the Treatment of Middle-aged and Elderly Patients with Heart Failure and Its influence on Neurohormones and Cardiac Function

目的:探究重组人脑利钠肽在中老年心力衰竭患者中的疗效及对神经激素、心功能的影响。方法:选取2020年1月-2022年2月北京市丰台中西医结合医院收治的81例中老年心力衰竭患者,根据随机数字表法将其分为对照组40例和观察组41例。对照组进行常规心力衰竭治疗,观察组则在对照组的基础上加用重组人脑利钠肽。比较两组的治疗效果(总有效率)、治疗前后的神经激素[血管紧张素Ⅱ(AngⅡ)、肾素活性(PRA)及去甲肾上腺素(NE)]、心功能指标[左室射血分数(LVEF)、左室舒张末期内径(LVEDD)及舒张早期血流速度峰值/舒张晚期血流速度峰值比值(E/A)]及心肌损伤指标[肌钙蛋白I(cTnI)及脑钠肽(BNP)]。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前两组神经激素、心功能指标及心肌损伤指标比较,差异均无统计学意义(P>0.05);治疗5、10 d两组神经激素、心功能指标及心肌损伤指标均优于治疗前,且观察组均优于对照组,差异均有统计意义(P<0.05)。结论:重组人脑利钠肽在中老年心力衰竭患者中的疗效较好,且可显著改善患者的神经激素及心功能状态,在中老年心力衰竭患者中的应用价值较高。

Objective:To investigate the effect of Recombinant Human Brain Natriuretic Peptide in the treatment of middle-aged and elderly patients with heart failure and its influence on neurohormones and cardiac function.Method:A total1 of 81 middle-aged and elderly patients with heart failure in Beijing Fengtai Hospital of Integrated Chinese and Western Medicine from January 2020 to February 2022 were selected,they were divided into control group 40 cases and observation group 41 cases by the random number table.The control group was treated with routine treatment of heart failure,the observation group was treated with Recombinant Human Brain Natriuretic Peptide on the basis of control group.The treatment effect(total effective rates),neurohormones[angiotensinⅡ(AngⅡ),plasma renin activity(PRA),norepinephrine(NE)],cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),end diastolic velocity/early diastolic peak velocity(E/A)]and myocardial injury indexes[cardiac troponin I(cTnI),brain natriuretic peptide(BNP)]before and after the treatment of two groups were compared.Result:The total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).There were no significant differences in neurohormones,cardiac function indexes and myocardial injury indexes between the two groups before treatment(P>0.05);after 5 and 10 d of treatment,neurohormones,cardiac function indexes and myocardial injury indexes in both groups were better than those before treatment,those in observation group were better than those in control group,the differences were statistically significant(P<0.05).Conclusion:The effect of Recombinant Human Brain Natriuretic Peptide in the treatment of middle-aged and elderly patients with heart failure is better,and it can significantly improve the expression of neurohormones and cardiac function state,so its application value in the middle-aged and elderly patients with heart failure is higher.