脑梗死合并高血压患者血清UA、Hcy水平与颈动脉粥样硬化的相关性

Correlation between UA and Hcy Levels and Carotid Atherosclerosis in Patients with Cerebral Infarction Complicated with Hypertension

目的:探讨脑梗死合并高血压患者血清尿酸(UA)、同型半胱氨酸(Hcy)水平与颈动脉粥样硬化的相关性。方法:选取2020年3月-2022年5月赣南医学院第一附属医院收治的118例脑梗死合并高血压患者,根据颈动脉粥样硬化诊断结果将患者分为无颈动脉粥样硬化组(n=31)和颈动脉粥样硬化组(n=87)。比较两组一般资料及UA、Hcy、血脂水平,并分析UA、Hcy与颈动脉粥样硬化的关系。结果:颈动脉粥样硬化组吸烟比例及UA、Hcy水平均高于无颈动脉粥样硬化组(P<0.05);多因素logistic回归分析显示,UA、Hcy是颈动脉粥样硬化发生的独立危险因素(P<0.05);Pearson相关分析显示,UA、Hcy与颈动脉内膜-中层厚度呈正相关(r=0.844、0.869,P<0.05)。结论:脑梗死合并高血压患者的血清UA、Hcy水平与颈动脉粥样硬化之间存在关联,且UA和Hcy水平升高是颈动脉粥样硬化发生的危险因素。

Objective:To investigate the correlation between serum uric acid(UA)and homocysteine(Hcy)levels and carotid atherosclerosis in patients with cerebral infarction complicated with hypertension.Method:A total of 118 patients with cerebral infarction complicated with hypertension admitted to First Affiliated Hospital of Gannan Medical University from March 2020 to May 2022 were selected and divided into non-carotid atherosclerosis group(n=31)and carotid atherosclerosis group(n=87)according to the diagnosis results of carotid atherosclerosis.The general data,UA,Hcy and blood lipid levels of the two groups were compared,and the relationship between UA,Hcy and carotid atherosclerosis was analyzed.Result:The smoking rate,UA and Hcy levels in carotid atherosclerosis group were higher than those in non-carotid atherosclerosis group(P<0.05).Multivariate logistic regression analysis showed that UA and Hcy were independent risk factors for carotid atherosclerosis(P<0.05).Pearson correlation analysis showed that UA and Hcy were positively correlated with carotid intima-media thickness(r=0.844,0.869,P<0.05).Conclusion:Serum UA and Hcy levels of patients with cerebral infarction complicated with hypertension are associated with carotid atherosclerosis,and the increased UA and Hcy levels are risk factors for the development of carotid atherosclerosis.